© 2008 Alexis Corporation
ALX-805-079 Revised 10-Nov-04
Monoclonal Antibody to CEACAM7 (human) (BAC2)
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SYNONYMS anti-CGM2 (human) MAb (BAC2)
PRODUCT LINE Cytoskeleton
PRODUCT CATEGORY CEACAM [CD66] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-805-079-C100   100 µg 290.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: BAC2
ISOTYPE: Mouse IgG1
CONCENTRATION: 1mg/ml.
FORMULATION: Liquid. Protein G affinity purified antibody in PBS, pH 7.2,  containing 0.01% sodium azide.
IMMUNOGEN: Recombinant human CEACAM7.
SPECIFICITY: Recognizes human CEACAM7. Does not cross-react with human CEACAM1, 3, 4, 5, 6, 8 or PSG.
APPLICATION: Flow Cytometry
Immunohistochemistry (frozen sections)
Optimal conditions must be determined individually for each application.
QUALITY CONTROL: Routinely tested by flow cytometry on BOSC23 cells transiently transfected with a CEACAM7 expression vector.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles. For maximum product recovery after thawing, centrifuge the vial before opening the cap.
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Product Specific Literature References
Molecular analysis of neisserial Opa protein interactions with the CEA family of receptors: identification of determinants contributing to the differential specificities of binding: A. Popp, et al.; Cell. Microbiol. 1, 169 (1999) Abstract; Full Text
Carcinoembryonic antigen family members CEACAM6 and CEACAM7 are differentially expressed in normal tissues and oppositely deregulated in hyperplastic colorectal polyps and early adenomas: S. Schölzel, et al.; Am. J. Pathol. 156, 595 (2000) Abstract; Full Text
General Information
CEA-related cell adhesion molecule 7 (CEACAM7, CGM2) belongs to the carcinoembryonic antigen (CEA) family. It encodes a glycosyl phosphatidyl inositol (GPI)-linked glycoprotein which is only found on the apical surface of highly differentiated epithelial cells of adult colon and on a small epithelial cell population in pancreatic ducts. CEACAM7 expression is completely lost upon malignant transformation already in hyperplastic polyps and early adenomas as well as in adenocarcinomas of the colon. Like all members of the CEACAM family it consists of a single N domain, with structural homology to the immunoglobulin variable domains, followed by one immunoglobulin constant-like A domain.
MANUFACTURER Manufactured by GENOVAC GmbH.
General Literature References
Carcinoembryonic antigen gene family: molecular biology and clinical perspectives: J.A. Thompson, et al.; J. Clin. Lab. Anal. 5, 344 (1991), (Review) Abstract
The carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissues: S. Hammarström; Semin. Cancer Biol. 9, 67 (1999), (Review) Abstract
Carcinoembryonic antigen: W. Zimmermann; Wliey Enyclopedia of Molecular Medicine (T. Creighton, ed.), John Wiley & Sons Inc., New York 459 (2002)
Further Categories Containing This Product:
CD Antibodies • Monoclonal Antibodies
 
 
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