© 2008 Alexis Corporation
ALX-350-325
Revised 25-Jun-07
Altenusin
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antibiotics - Antifungal
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-350-325-M001
1 mg
110.00 USD
ALX-350-325-M005
5 mg
380.00 USD
Product Specification
FORMULA:
C
15
H
14
O
6
MW:
290.3
CAS NUMBER:
31186-12-6
SOURCE/HOST:
Isolated from
Alternaria sp
.
PURITY:
≥97% (HPLC)
APPEARANCE:
Yellow to brown solid.
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
IDENTITY:
Identity determined by
1
H-NMR,
13
C-NMR and MS.
Product Description
Antifungal penicillide. Non-competitive, specific neutral sphingomyelinase (N-SMase) and strong pp60c-Src inhibitor. Inhibits cFMS receptor tyrosine kinase (CSF-1/m-CSF receptor tyrosine kinase) which is implicated in cancer and bone diseases. Myosin light chain kinase inhibitor. Exhibits anti-HIV-1 integrase activity.
Product Specific Literature References
Studies in the biochemistry of micro-organisms. 103. Metabolites of Alternaria tenuis Auct.: Culture filtrate products:
T. Rosett, et al.; Biochem. J.
67
, 390 (1957)
Full Text
Studies in the biosynthesis of fungal metabolites. 4. Alternariol monomethyl ether and its relation to other phenolic metabolites of Alternaria tenuis:
R. Thomas; Biochem. J.
80
, 234 (1961)
Abstract
;
Full Text
Metabolites of some Alternaria species. The structures of altenusin and dehydroaltenusin:
R. G. Coombe, et al.; Aus. J. Chem.
23
, 2343 (1970)
Host-specific toxins and chemical structures from alternaria species:
S. Nishimura, et al.; Ann. Rev. Phytopathol.
21
, 87 (1983)
The metabolites of Talaromycesflavus: Part 1. Metabolites of the organic extracts :
W. A. Ayer, et al.; Can. J. Chem.
68
, 2085 (1990)
Isolation of myosin light chain kinase inhibitors from microorganisms: dehydroaltenusin, altenusin, atrovenetinone, and cyclooctasulfur:
S. Nakanishi, et al.; Biosci. Biotechnol. Biochem.
59
, 1333 (1995)
Abstract
Alutenusin, a specific neutral sphingomyelinase inhibitor, produced by Penicillium sp. FO-7436:
R. Uchida, et al.; J. Antibiot.
52
, 572 (1999)
Abstract
Isolation, structure, and HIV-1-integrase inhibitory activity of structurally diverse fungal metabolites:
S.B. Singh, et al.; J. Ind. Microbiol. Biotechnol.
30
, 721 (2003)
Abstract
Fungal metabolites as potent protein kinase inhibitors: Identification of a novel metabolite and novel activities of known metabolites :
M. Oyama, et al.; Lett. Drug Design Discov.
1
, 24 (2004)
New penicillide derivatives isolated from Penicillium simplicissimum:
S. I. Komai, et al.; J. Nat. Med.
60
, 185 (2006)
HIV-1 integrase inhibitors: 2003-2004 update:
R. Dayam, et al.; Med. Res. Rev.
26
, 271 (2006)
Abstract
Further Categories Containing This Product:
Tyrosine Kinase Inhibitors
•
Myosin Light Chain Kinase Inhibitors
•
Antibiotics - Antiviral/Anti-HIV
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