ALEXIS Biochemicals: Mezerein (high purity)

ALX-350-042

Revised 07-Apr-08

Mezerein (high purity)
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Other Signal Transduction Pathway Modulators

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-042-M001		1 mg	70.00 USD

Product Specification

FORMULA:	C₃₈H₃₈O₁₀
MW:	654.7
CAS NUMBER:	34807-41-5
SOURCE/HOST:	Isolated from Daphne mezereum.
PURITY:	≥98%
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in 100% ethanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HAZARD:	IRRITANT. TUMOR PROMOTER.

Product Description

Protein kinase C (PKC) activator. Second stage tumor promoter whereas phorbol-12-myristate 13-acetate (PMA) (Prod. No. ALX-445-004) is a first stage tumor promoter. May be of use for studying phorbol ester receptor isotypes. Induces interleukin-1α. Coinducer of interferon with phytohemagglutinin.

Product Specific Literature References

Studies on the mechanism of skin tumor promotion: evidence for several stages in promotion: T.J. Slaga, et al.; PNAS 77, 3659 (1980) Abstract
Two phorbol ester receptor affinities in partially transformed human urothelial cells and decrease of receptor binding in desensitized cells: B. Christensen, et al.; Experientia 49, 80 (1993) Abstract
Relationship between mezerein-mediated biological responses and phorbol ester receptor occupancy: S. Jaken, et al.; Cancer Res. 43, 11 (1983) Abstract
Modulation of interleukin-1 alpha mRNA expression in mouse epidermis by tumor promoters and antagonists: W.Y. Lee, et al.; Mol. Carcinog. 7, 26 (1993) Abstract
Induction of differentiation in human promyelocytic HL-60 leukemia cells activates p21, WAF1/CIP1, expression in the absence of p53: H. Jiang, et al.; Oncogene 9, 3397 (1994) Abstract
Stimulation of calcium sequestration by mezerein, a protein kinase C activator, in saponized rabbit platelets: H. Nishio, et al.; Gen. Pharmacol. 25, 413 (1994) Abstract

Further Categories Containing This Product:

Carcinogens & Tumor Promoters Other Products • PKC Activators • Natural Products - Other Tumor Promoters

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