ALEXIS Biochemicals: Josamycin

ALX-380-078

Revised 07-Apr-08

Josamycin
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Other Antibiotics for Cancer Research

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-380-078-M100		100 mg	30.00 USD

Product Specification

FORMULA:	C₄₂H₆₉NO₁₅
MW:	828.0
CAS NUMBER:	16846-24-5
MERCK INDEX:	14: 5267
RTECS:	OH4725810
SOURCE/HOST:	Isolated from Streptomyces narbonenensis, var. josamyceticus nov. var.
PURITY:	≥98%
APPEARANCE:	White to off-white powder.
SOLUBILITY:	Soluble in methanol, 100% ethanol, acetone, ethyl acetate, dioxane, or acidic water.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	+4°C

Product Description

Macrolide antibiotic that may overcome anticancer drug resistance by inhibiting the binding of vinblastine (Prod. No. ALX-350-257) or cyclosporin A (Prod. No. ALX-380-002) to P-glycoprotein (Pgp).

Product Specific Literature References

A new antibiotic, josamyicn. I. Isolation and physico-chemical characteristics: T. Osono, et al.; J. Antibiot. (Tokyo) 20, 174 (1967) Abstract
Reversal of anticancer drug resistance by macrolide antibiotics in vitro and in vivo: L. Wang, et al.; Clin. Exp. Pharmacol. Physiol. 27, 587 (2000) Abstract
Kinetics of macrolide action: the josamycin and erythromycin cases: M. Lovmar, et al.; J. Biol. Chem. 279, 53506 (2004) Abstract

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