ALEXIS Biochemicals: Berberine . hemisulfate

ALX-350-094

Revised 24-Jul-08

Berberine . hemisulfate
SYNONYMS	Natural Yellow 18 5,6-Dihydro-9,10-dimethoxybenzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products with Antibiotic Activity

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-094-G001		1 g	15.00 USD

Product Specification

FORMULA:	C₂₀H₁₈NO₄. 0.5SO₄
MW:	336.4 . 48.0
CAS NUMBER:	633-66-9
MERCK INDEX:	14: 1154
RTECS:	DR9867000
PURITY:	≥98% (TLC)
APPEARANCE:	Off-white to yellow powder.
SOLUBILITY:	50mg/ml soluble in methanol:water 2:1.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+20°C
HAZARD:	TOXIC.
IDENTITY:	Determined by IR: Identical to standard reference.

Product Description

Alkaloid which exhibits relatively weak antibiotic properties, because of its efflux by multidrug resistance pumps. The antimicrobial action of berberine is potentiated by 5’-methoxyhydnocarpin, a multidrug pump inhibitor. Lowers cholesterol levels through a mechanism different from that of statins. Upregulates the expression of liver low-density lipoprotein receptor (LDLR) resulting in improved clearance of plasma LDL cholesterol through receptor mediated endocytosis. Possesses anti-inflammatory, anti-diabetic and anti-angiogenic effects. Induces apoptosis.

Product Specific Literature References

Berberine sulfate: antimicrobial activity, bioassay, and mode of action: A.H. Amin, et al.; Can. J. Microbiol. 15, 1067 (1969) Abstract
Bacteria lacking a multidrug pump: a sensitive tool for drug discovery: P.C. Hsieh, et al.; PNAS 95, 6602 (1998) Abstract; Full Text
Synergy in a medicinal plant: antimicrobial action of berberine potentiated by 5’-methoxyhydnocarpin, a multidrug pump inhibitor: F.R. Stermitz, et al.; PNAS 97, 1433 (2000) Abstract; Full Text
Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins: W. Kong, et al.; Nat. Med. 10, 1344 (2004) Abstract
The anti-inflammatory potential of berberine in vitro and in vivo: C.L. Kuo, et al.; Cancer Lett. 203, 127 (2004) Abstract
Therapeutic effects of berberine in impaired glucose tolerance rats and its influence on insulin secretion: S.H. Leng, et al.; Acta Pharmacol. Sin. 25, 496 (2004) Abstract
Berberine inhibits HIF-1alpha expression via enhanced proteolysis: S. Lin, et al.; Mol. Pharmacol. 66, 612 (2004) Abstract
Apoptosis of human leukemia HL-60 cells and murine leukemia WEHI-3 cells induced by berberine through the activation of caspase-3: C.C. Lin, et al.; Anticancer Res. 26, 227 (2006) Abstract
Berberine acutely inhibits insulin secretion from beta cells through cAMP signaling pathway: L. Zhou, et al.; Endocrinology (2008) Abstract
Berberine modifies cysteine 179 of IkappaBalpha kinase, suppresses nuclear factor-kappaB-regulated antiapoptotic gene products, and potentiates apoptosis.: M.K. Pandey, et al.; Cancer Res. 68, 5370 (2008) Abstract

Further Categories Containing This Product:

Natural Products - Anti-inflammatory Agents • Natural Products - Chemopreventive Agents • Antidiabetic Agents/Related Products • Cholesterol & Lipid Transport/Related Products • Alkaloids

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