ALEXIS Biochemicals: Bisbenzimide H33342 . trihydrochloride

ALX-620-050

Revised 02-Sep-05

Bisbenzimide H33342 . trihydrochloride
SYNONYMS	HOE 33342 2'-(4-Ethoxyphenyl)-5-(4-methyl-1-piperazinyl)-2,5'-bis-1H-benzimidazole . 3HCl
PRODUCT LINE	Other Products
PRODUCT CATEGORY	Dyes / Stains / Fluorescent Probes / Fluorescent Labels

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-620-050-M010		10 mg	22.00 USD
ALX-620-050-M050		50 mg	35.00 USD

Product Specification

FORMULA:	C₂₇H₂₈N₆O . 3HCl
MW:	452.6 . 109.4
CAS NUMBER:	23491-52-3
PURITY:	≥95%
APPEARANCE:	Yellow to green powder.
SOLUBILITY:	Soluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HANDLING:	Protect from light.
HAZARD:	TOXIC. MAY BE CARCINOGENIC.

Product Description

Cell permeable fluorescent dye that binds to A:T pairs in DNA [1]. Useful for the simultaneous study of the cell cycle and apoptosis in unfixed cells [2]. Also useful for controlling gene expression through binding to RNA aptamers inserted into 5' untranslated region of a messenger RNA [3]. Induces cell differentiation. About 10 times more cell permeable than bisbenzimide H33258 (Prod. No. ALX-620-051). Ex(max): 346nm; Em(max): 460nm.

Product Specific Literature References

[1] Spectral studies on 33258 Hoechst and related bisbenzimidazole dyes useful for fluorescent detection of deoxyribonucleic acid synthesis: S.A. Latt & G. Stetten; J. Histochem. Cytochem. 24, 24 (1976) Abstract
[2] A flow cytometric method using Hoechst 33342 and propidium iodide for simultaneous cell cycle analysis and apoptosis determination in unfixed cells: F. Belloc, et al.; Cytometry 17, 59 (1994) Abstract
[3] Controlling gene expression in living cells through small molecule-RNA interactions: G. Werstuck & M.R. Green; Science 282, 296 (1998) Abstract

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Apoptosis Inducers & Inhibitors Other Products • MDR Other Products

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