ALEXIS Biochemicals: Hymenidin

ALX-350-291

Revised 19-Oct-07

Hymenidin
SYNONYMS	2-Debromooroidin
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products for Cell Cycle Research

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-291-M001		1 mg	230.00 USD

Product Specification

FORMULA:	C₁₁H₁₂BrN₅O
MW:	310.2
CAS NUMBER:	107019-95-4
SOURCE/HOST:	Isolated from Hymeniacidon sp.
PURITY:	≥95%
APPEARANCE:	Amorphous solid.
SOLUBILITY:	Soluble in DMSO or 100 % ethanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light.
HAZARD:	TOXIC. CYTOTOXIC.

Product Description

Antagonist of serotonergic receptors. Inhibitor of CDK5/p25 (IC₅₀=4µM) and GSK-3β (IC₅₀=12µM).

Product Specific Literature References

A novel antagonist of serotonergic receptors, hymenidin, isolated from the Okinawan marine sponge Hymeniacidon sp: J. Kobayashi, et al.; Experientia 42, 1176 (1986) Abstract
Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a marine sponge constituent: L. Meijer, et al.; Chem. Biol. 7, 51 (2000)
Brominated pyrrole alkaloids from marine Agelas sponges reduce depolarization-induced cellular calcium elevation: U. Bickmeyer, et al.; Toxicon. 44, 45 (2004) Abstract
Marine compounds for the therapeutic treatment of neurological disorders: D. Alonso, et al.; Expert Opininon on Therapeutic Patents 15, 1377 (2005)

Further Categories Containing This Product:

CDK & Cyclin Inhibitors • Natural Products for Neurological Research • Serotonergics & Serotonin Receptors / Related Products • Alkaloids

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