© 2008 Alexis Corporation
ALX-270-403
Revised 12-Jun-08
2-Bromo-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
PRODUCT LINE
Cell Cycle
PRODUCT CATEGORY
CDK & Cyclin Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-403-M001
1 mg
115.00 USD
Product Specification
FORMULA:
C
20
H
10
BrN
3
O
2
MW:
404.2
PURITY:
≥95% (HPLC)
APPEARANCE:
Yellow solid.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
+4°C
USE/STABILITY:
Stock solutions are stable for up to 2 months if stored at -20°C.
HANDLING:
Packaged under inert gas. Protect from light. After reconstitution, prepare aliquots and store at -20°C.
HAZARD:
TOXIC.
IDENTITY:
Identity determined by NMR.
Product Description
Cell permeable, unsymmetrical compound that displays antiproliferative properties. Potent, selective and ATP-competitive inhibitor of CDK4/cyclin D1 (IC
50
=76nM), CDK2/cyclin E (IC
50
=520nM) and CDK1/cyclin B (IC
50
=2.1µM). Shows little activity towards CaMKII, PKA and GSK-3β (IC
50
>20µM).
Product Specific Literature References
Synthesis, structure-activity relationship, and biological studies of indolocarbazoles as potent cyclin D1-CDK4 inhibitors
:
G. Zhu, et al.; J. Med. Chem.
46
, 2027 (2003)
Abstract
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