ALEXIS Biochemicals: Monoclonal Antibody to CD66e (human) (26/3/13)

ALX-805-077

Revised 14-Sep-07

Monoclonal Antibody to CD66e (human) (26/3/13)
SYNONYMS	anti-CEACAM5 (human) MAb (26/3/13) anti-CEA (human) MAb (26/3/13) anti-Carcinoembryonic Antigen (human) MAb (26/3/13)
PRODUCT LINE	Cytoskeleton
PRODUCT CATEGORY	CEACAM [CD66] / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-805-077-C100		100 µg	290.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human
CLONE:	26/3/13
ISOTYPE:	Mouse IgG1
CONCENTRATION:	1mg/ml
PURITY DETAIL:	Protein G-affinity purified.
FORMULATION:	Liquid. In PBS, pH 7.2, containing 0.01% sodium azide.
IMMUNOGEN:	CD66e (CEACAM5; CEA) partially purified from a perchloric acid extract from liver metastases of colonic tumors.
SPECIFICITY:	Recognizes human CD66e. Does not cross-react with human CEACAM1, 3, 4, 6, 7, 8 or PSG.
APPLICATION:	ELISA Flow Cytometry Immunohistochemistry (frozen sections) Western Blot Optimal conditions must be determined individually for each application.
QUALITY CONTROL:	Routinely tested by flow cytometry on BOSC cells transiently transfected with a CD66e expression vector.
SHIPPING:	SHIPPED ON BLUE ICE
SHORT TERM STORAGE:	+4°C
LONG TERM STORAGE:	-20°C
HANDLING:	For maximum product recovery after thawing, centrifuge the vial before opening the cap. Avoid freeze/thaw cycles.

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Product Specific Literature References

Two CEA and three NCA species, although distinguishable by monoclonal antibodies, have nearly identical peptide patterns: F. Grunert, et al.; Int. J. Cancer 36, 357 (1985) Abstract
Effects of human bone marrow stroma on the growth of human tumor cells: E.S. Strobel, et al.; Cancer Res. 49, 1001 (1989) Abstract
A polymerase-chain-reaction assay for the specific identification of transcripts encoded by individual carcinoembryonic antigen (CEA)-gene-family members: J. Thompson, et al.; Int. J. Cancer 55, 311 (1993) Abstract
CD66 family workshop: binding of myeloid blind panel antibodies and CD66 Subsection antibodies to HeLa transfectants expressing individual CD66 molecules: F. Grunert, et al.; Leukocyte Typing VI: White cell Differentiation Antigens (T. Kishimoto, et al., eds.), Garland Publishing Inc., New York and London 1012 (1996)
CEA-related proteins on human urothelial cell lines of different transformation grades: A. Krop-Watorek, et al.; Cancer Lett. 139, 15 (1999) Abstract
Carcinoembryonic antigen family members CEACAM6 and CEACAM7 are differentially expressed in normal tissues and oppositely deregulated in hyperplastic colorectal polyps and early adenomas: S. Scholzel, et al.; Am. J. Pathol. 156, 595 (2000) Abstract; Full Text

General Information

CD66e (CEACAM5; CEA) belongs to the carcinoembryonic antigen (CEA) gene family. It encodes a glycosyl phosphatidyl inositol (GPI)-linked glycoprotein with a M_r of 180'000-200'000 which is most strongly expressed on epithelial cells of the fetal and adult colon and to a minor extent on epithelial cells of the stomach and sweat glands, squamous epithelial cells of the tongue, esophagus and cervix. CD66e is used as a tumor marker for early detection of recurrent disease due to its expression in adenocarcinomas of the colon, lung, breast, stomach and pancreas and in mucinous ovarian carcinomas. Like all members of the CEACAM family, it consists of a single N domain, with structural homology to the immunoglobulin variable domains, followed by six immunoglobulin constant-like A (A1, A2, A3) and B domains (B1, B2, B3).

MANUFACTURER

Manufactured by GENOVAC GmbH.

General Literature References

Carcinoembryonic antigen gene family: molecular biology and clinical perspectives: J.A. Thompson, et al.; J. Clin. Lab. Anal. 5, 344 (1991), (Review) Abstract
The carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissues: S. Hammarström; Semin. Cancer Biol. 9, 67 (1999), (Review) Abstract
Carcinoembryonic antigen: W. Zimmermann; Wiley Encyclopedia of Molecular Medicine (T. Creighton, ed.), John Wiley & Sons Inc., New York 459 (2002)

Further Categories Containing This Product:

CD Antibodies • Monoclonal Antibodies

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