© 2008 Alexis Corporation
ALX-380-075 Revised 03-Apr-08
Antimycin A
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SYNONYMS Antipiricullin
Virosin
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Apoptosis Inducers & Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-075-M005   5 mg 20.00 USD Add To Cart
ALX-380-075-M010   10 mg 33.00 USD Add To Cart
Product Specification
CAS NUMBER: 1397-94-0
MERCK INDEX: 14: 714 (A1) & 715 (A3)
RTECS: CD0350000
SOURCE/HOST: Isolated from Streptomyces sp. Mixture of antimycin A's.
APPEARANCE: White to faint yellow powder.
SOLUBILITY: Soluble in 100% ethanol (50mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: TOXIC.

Product Description
Antibiotic. Induces apoptosis, which is not prevented by the presence of Bcl-2. Inhibits mitochondrial electron transport specifically between cytochromes b and c1.
Product Specific Literature References
The isolation and properties of antimycin A: B. R. Dunshee, et al.; J. Am. Chem. Soc. 71, 2436 (1949)
The effect of antimycin A on mouse liver inner mitochondrial membrane channel activity: M.L. Campo, et al.; J. Biol. Chem. 267, 8123 (1992) Abstract; Full Text
Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3: S.P. Tzung, et al.; Nat. Cell Biol. 3, 183 (2001) Abstract
Biophysical characterization of recombinant human Bcl-2 and its interactions with an inhibitory ligand, antimycin A: K.M. Kim, et al.; Biochemistry 40, 4911 (2001) Abstract
Synthetic peptides and non-peptidic molecules as probes of structure and function of Bcl-2 family proteins and modulators of apoptosis: D. Liu & Z. Huang; Apoptosis 6, 453 (2001) Abstract
Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3: S.P. Tzung, et al.; Nat. Cell. Biol. 3, 183 (2001) Abstract
Oligomycin and antimycin A prevent nitric oxide-induced apoptosis by blocking cytochrome C leakage: N. Dairaku, et al.; J. Lab. Clin. Med. 143, 143 (2004) Abstract
An ROS generator, antimycin A, inhibits the growth of HeLa cells via apoptosis: W.H. Park, et al.; J. Cell. Biochem. 102, 98 (2007) Abstract
Further Categories Containing This Product:
Bcl-2 Family Modulators • Respiratory Chain Other Products
 
 
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