© 2008 Alexis Corporation
ALX-260-071
Revised 14-Oct-05
Boc-D(OMe)-FMK
SYNONYMS
Caspase Family Inhibitor (Fluoromethylketone)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-071-M001
1 mg
210.00 USD
ALX-260-071-M005
5 mg
880.00 USD
Product Specification
SEQUENCE:
Boc-Asp(OMe)-fluoromethylketone
FORMULA:
C
11
H
18
FNO
5
MW:
263.3
PURITY:
≥98% (TLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in DMSO or dimethyl formamide.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stock solutions should be divided into aliquots and stored at -20°C. For long term storage keep aliquots at -70°C.
HANDLING:
Keep cool and dry. After reconstitution, prepare aliquots and store at -80°C.
Product Description
Irreversible, cell permeable broad-spectrum caspase inhibitor.
Product Specific Literature References
Different interleukin-1 beta converting enzyme (ICE) family protease requirements for the apoptotic death of T lymphocytes triggered by diverse stimuli
:
A. Sarin, et al.; J. Exp. Med.
184
, 2445 (1996)
Abstract
Caspase inhibitor BD-fmk distinguishes transforming growth factor β-induced apoptosis from growth inhibition
:
T.L. Brown, et al.; Cell Growth Differ.
9
, 869 (1998)
Abstract
Caspase inhibitor affords neuroprotection with delayed administration in a rat model of neonatal hypoxic-ischemic brain injury
:
Y. Cheng, et al.; J. Clin. Invest.
101
, 1992 (1998)
Abstract
;
Full Text
A DEVD-inhibited caspase other than CPP32 is involved in the commitment of cerebellar granule neurons to apoptosis induced by K+ deprivation:
S.R. D'Mello, et al.; J. Neurochem.
70
, 1809 (1998)
Abstract
The neuroprotective effect of pituitary adenylate cyclase-activating polypeptide on cerebellar granule cells is mediated through inhibition of the CED3-related cysteine protease caspase-3/CPP32
:
D. Vaudry, et. al.; PNAS
97
, 13390 (2000)
Abstract
;
Full Text
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