© 2008 Alexis Corporation
ALX-260-056
Revised 11-Dec-07
Ac-ESMD-CHO
SYNONYMS
Caspase-8 Inhibitor (Aldehyde)
Granzyme B Inhibitor (Aldehyde)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-056-M001
1 mg
83.00 USD
ALX-260-056-M005
5 mg
325.00 USD
Product Specification
SEQUENCE:
Ac-Glu-Ser-Met-Asp-CHO
FORMULA:
C
19
H
30
N
4
O
10
S
MW:
506.5
PEPTIDE CONTENT:
70-90%.
PURITY:
≥99% (HPLC)
APPEARANCE:
White powder.
FORMULATION:
Lyophilized.
SOLUBILITY:
Soluble in distilled water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Use always fresh solutions.
HANDLING:
Keep cool and dry. Keep under inert gas.
Product Description
Reversible inhibitor of caspase-8 and granzyme B. Also inhibits caspase-6 and -10. The peptide sequence corresponds to one of the cleavage sites of the inactive 32kDa caspase-3 precursor (aa 25-28). It blocks the formation of the p17 subunit and concomitantly induces the accumulation of the p20 peptide.
Product Specific Literature References
A sequential two-step mechanism for the production of the mature p17:p12 form of caspase-3 in vitro:
Z. Han, et al.; J. Biol. Chem.
272
, 13432 (1997)
Abstract
;
Full Text
Further Categories Containing This Product:
Granzyme Inhibitors
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