© 2008 Alexis Corporation
ALX-270-314
Revised 04-Dec-07
CL-387,785
SYNONYMS
EKI-785
N-[4-[(3-Bromophenyl)amino]-6-quinazolinyl]-2-butynamide
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
EGFR Kinase Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-314-M001
1 mg
130.00 USD
Product Specification
FORMULA:
C
18
H
13
BrN
4
O
MW:
381.2
PURITY:
≥98% (HPLC)
APPEARANCE:
Off-white to yellow solid.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Hygroscopic. Protect from light. Packaged under inert gas.
Product Description
Irreversibly inhibits EGF-stimulated autophosphorylation of tyrosine residues in the epidermal growth factor receptor (EGFR)
in vivo
(IC
50
=250-490pM) and blocks EGF-mediated growth.
Product Specific Literature References
Irreversible inhibition of epidermal growth factor receptor tyrosine kinase with in vivo activity by N-[4-[(3-bromophenyl)amino]-6-quinazolinyl]-2-butynamide (CL-387,785)
:
C.M. Discafani, et al.; Biochem. Pharmacol.
57
, 917 (1999)
Abstract
© 2008 ALEXIS Corporation,
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