© 2008 Alexis Corporation
ALX-260-030
Revised 05-Jun-08
Ac-DEVD-CHO
SYNONYMS
Caspase-3 Inhibitor (Aldehyde)
Caspase-7 Inhibitor (Aldehyde)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-030-M001
1 mg
47.00 USD
ALX-260-030-M005
5 mg
183.00 USD
Product Specification
SEQUENCE:
Ac-Asp-Glu-Val-Asp-CHO
FORMULA:
C
20
H
30
N
4
O
11
MW:
502.5
PEPTIDE CONTENT:
70-90%.
PURITY:
≥95% (HPLC)
FORMULATION:
Lyophilized.
SOLUBILITY:
Soluble in distilled water or DMSO.
RECONSTITUTION:
Add 0.2ml DMSO per 1mg peptide. Shake well until all the contents are dissolved. This furnishes a 10mM solution of this material.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stock solutions should be divided into aliquots and stored at -20°C. Solutions are stable for at least 1 month when stored at -20°C in the dark and protected from moisture.
HANDLING:
Keep cool and dry. Keep under nitrogen.
Product Description
Reversible inhibitor of caspase-3 and -7.
Product Specific Literature References
Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis:
D.W. Nicholson, et al.; Nature
376
, 37 (1995)
Abstract
Sequential activation of ICE-like and CPP32-like proteases during Fas- mediated apoptosis:
M. Enari, et al.; Nature
380
, 723 (1996)
Abstract
ICE/CED3-like proteases as therapeutic targets for the control of inappropriate apoptosis:
D.W. Nicholson; Nature Biotechnol.
14
, 297 (1996)
Abstract
CPP32/apopain is a key interleukin 1 beta converting enzyme-like protease involved in Fas-mediated apoptosis:
J. Schlegel, et al.; J. Biol. Chem.
271
, 1841 (1996)
Abstract
;
Full Text
A sequential two-step mechanism for the production of the mature p17:p12 form of caspase-3 in vitro:
Z. Han, et al.; J. Biol. Chem.
272
, 13432 (1997)
Abstract
;
Full Text
Inhibition of human caspases by peptide-based and macromolecular inhibitors:
M. Garcia-Calvo, et al.; J. Biol. Chem.
273
, 32608 (1998)
Abstract
;
Full Text
Inhibition of ubiquitin-proteasome pathway activates a caspase-3-like protease and induces Bcl-2 cleavage in human M-07e leukaemic cells:
X.M. Zhang, et al.; Biochem. J.
340
, 127 (1999)
Abstract
;
Full Text
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