© 2008 Alexis Corporation
ALX-430-026
Revised 12-Sep-06
Calmidazolium chloride
SYNONYMS
1-[
bis
(p-Chlorophenyl)methyl]-3-[2,4-dichloro-β-(2,4-dichlorobenzyloxy)phenethyl] imidazolium chloride
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Calmodulin Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-430-026-M010
10 mg
85.00 USD
ALX-430-026-M050
50 mg
340.00 USD
Product Specification
FORMULA:
C
31
H
23
Cl
7
N
2
O
MW:
687.7
CAS NUMBER:
57265-65-3
PURITY:
≥98%
APPEARANCE:
White powder.
SOLUBILITY:
Soluble in methanol, 100% ethanol, chloroform, DMSO or propylene glycol; almost insoluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
Product Description
Calmodulin antagonist. At least 150 times more potent than trifluoperazine (Prod. No.
ALX- 550-310
) as an inhibitor of brain calmodulin-dependent phosphodiesterase. Inhibitor of voltage-gated Ca
2+
channels. Blocks Ca
2+
-calmodulin binding to NOS.
Product Specific Literature References
Inhibitors of calmodulin impair the constitutive but not the inducible nitric oxide synthase activity in the rat aorta:
V.B. Schini & P.M. Vanhoutte; J. Pharmacol. Exp. Ther.
261
, 553 (1992)
Abstract
Calmidazolium, a calmodulin inhibitor, inhibits endothelium-dependent relaxations resistant to nitro-L-arginine in the canine coronary artery:
S. Illiano, et al.; Br. J. Pharmacol.
107
, 387 (1992)
Abstract
The calmodulin antagonist calmidazolium stimulates release of nitric oxide in neuroblastoma N1E-115 cells:
J. Hu & E.E. el-Fakahany; Neuroreport
4
, 198 (1993)
Abstract
Vasoactive intestinal peptide/pituitary adenylate cyclase-activating peptide-dependent activation of membrane-bound NO synthase in smooth muscle mediated by pertussis toxin-sensitive Gi1-2:
K.S. Murthy & G.M. Makhlouf; J. Biol. Chem.
269
, 15977 (1994)
Abstract
Mitochondrial nitric oxide synthase is constitutively active and is functionally upregulated in hypoxia:
Z. Lacza, et al.; Free Radic. Biol. Med.
31
, 1609 (2001)
Abstract
Mitochondrial calcium uptake stimulates nitric oxide production in mitochondria of bovine vascular endothelial cells:
E.N. Dedkova, et al.; Am. J. Physiol. Cell Physiol.
286
, C406 (2004)
Abstract
;
Full Text
Neural tube closure depends on nitric oxide synthase activity:
A. Nachmany, et al.; J. Neurochem.
96
, 247 (2006)
Abstract
Further Categories Containing This Product:
NOS Other Products
•
Ca2+ Channels (L-type)
•
Phosphodiesterases / Related Products
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