ALEXIS Biochemicals: N-Oxalylglycine

ALX-270-412

Revised 25-Nov-08

N-Oxalylglycine
SYNONYMS	NOG
PRODUCT LINE	Oxidative Stress
PRODUCT CATEGORY	Hypoxia-inducible Factor [HIF] / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-412-M010		10 mg	40.00 USD
ALX-270-412-M050		50 mg	120.00 USD

Product Specification

FORMULA:	C₄H₅NO₅
MW:	147.1
CAS NUMBER:	5262-39-5
PURITY:	≥98%
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in water or DMSO.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stable for at least 1 year after receipt when stored at -20°C.
HANDLING:	Hygroscopic.
HAZARD:	IRRITANT.
IDENTITY:	Identity determined by ¹H-NMR and ¹³C-NMR.

Product Description

Cell permeable, competitive inhibitor of PHDs (prolyl hydroxylase domain-containing proteins; HIF-PHs).

Product Specific Literature References

Novel inhibitors of prolyl 4-hydroxylase. 3. Inhibition by the substrate analogue N-oxaloglycine and its derivatives: C.J. Cunliffe, et al.; J. Med. Chem. 35, 2652 (1992) Abstract

General Literature References

Inhibition of prolyl 4-hydroxylase by oxalyl amino acid derivatives in vitro, in isolated microsomes and in embryonic chicken tissues: E. Baader, et al.; Biochem. J. 300, 525 (1994) Abstract
Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation: P. Jaakkola, et al.; Science 292, 468 (2001) Abstract
C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation: A.C. Epstein, et al.; Cell 107, 43 (2001) Abstract
Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha: J.M. Elkins, et al.; J. Biol. Chem. 278, 1802 (2003) Abstract
Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases: P. Koivunen, et al.; J. Biol. Chem. 279, 9899 (2004) Abstract

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