ALEXIS Biochemicals: BAY 11-7085

ALX-270-220

Revised 04-Nov-05

BAY 11-7085
SYNONYMS	(E)-3-(t-Butylphenylsulfonyl)-2-propenenitrile
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	NF-kB Pathway Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-220-M010		10 mg	60.00 USD

Product Specification

FORMULA:	C₁₃H₁₅NO₂S
MW:	249.3
CAS NUMBER:	196309-76-9
PURITY:	≥98%
APPEARANCE:	White to off-white crystalline powder.
SOLUBILITY:	Soluble in DMSO or ethanol; insoluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light. Keep under inert gas.

Product Description

Has biological properties very similar to those of BAY 11-7082 (Prod. No. ALX-270-219). In addition, the product exhibits potent anti-inflammatory properties in vivo.

Product Specific Literature References

Novel inhibitors of cytokine-induced IkappaBalpha phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo: J.W. Pierce, et al.; J. Biol. Chem. 272, 21096 (1997) Abstract; Full Text
Pharmacologic interference with NF-kappaB activation attenuates central nervous system complications in experimental Pneumococcal meningitis: U. Koedel, et al.; J. Infect Dis. 182, 1437 (2000) Abstract
Neuronal injury-induced expression and release of apolipoprotein E in mixed neuron/glia co-cultures: nuclear factor kappaB inhibitors reduce basal and lesion-induced secretion of apolipoprotein E: V. Petegnief, et al.; Neuroscience 104, 223 (2001) Abstract

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