© 2008 Alexis Corporation
ALX-157-020
Revised 03-Mar-05
Galanin Like Peptide [GALP] (1-60) (pig)
PRODUCT LINE
Obesity & Adipokines
PRODUCT CATEGORY
Galanin & Galanin Receptor / Related Products
Ordering Information
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ALX-157-020-MC01
0.1 mg
490.00 USD
Product Specification
SEQUENCE:
H-Ala-Pro-Val-His-Arg-Gly-Arg-Gly-Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-Val-Leu-His-Pro-Pro-Ser-Arg-Ala-Glu-Gly-Gly-Gly-Lys-Gly-Lys-Thr-Ala-Leu-Gly-Ile-Leu-Asp-Leu-Trp-Lys-Ala-Ile-Asp-Gly-Leu-Pro-Tyr-Pro-Gln-Ser-Gln-Leu-Ala-Ser-OH
FORMULA:
C
281
H
443
N
81
O
78
MW:
6204.1
CAS NUMBER:
245114-96-9
SOURCE/HOST:
Isolated from pig hypothalamus.
PURITY:
≥95%
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
GALP is a 60 amino acid peptide that, unlike galanin, has a non-amidated C-terminus. GALP (aa 9-21) is identical to the biologically active N-terminal (aa 1-13) portion of galanin. Receptor binding studies revealed that GALP has a high affinity for the galanin receptor 2 (IC
50
=0.24nM) and a lower affinity for the galanin receptor 1 (IC
50
=0.48nM). GALP is therefore an endogenous ligand that preferentially binds to galanin receptor 2, whereas galanin is relatively non-selective.
Product Specific Literature References
Isolation and cDNA cloning of a novel galanin-like peptide (GALP) from porcine hypothalamus
:
T. Ohtaki, et al.; J. Biol. Chem.
274
, 37041 (1999)
Abstract
;
Full Text
Galanin-like peptide (GALP) is a target for regulation by leptin in the hypothalamus of the rat
:
A. Jureus, et al.; Endocrinology
141
, 2703 (2000)
Abstract
;
Full Text
Galanin-like peptide (GALP) mRNA expression is restricted to arcuate nucleus of hypothalamus in adult male rat brain
:
J.A. Larm & A.L. Gundlach; Neuroendocrinology
72
, 67 (2000)
Abstract
Further Categories Containing This Product:
Peptides
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