ALEXIS Biochemicals: Monoclonal Antibody to RANKL (12A380)

ALX-804-244

Revised 20-Aug-07

Monoclonal Antibody to RANKL (12A380)
SYNONYMS	anti-ODF MAb (12A380) anti-OPGL MAb (12A380) anti-TRANCE MAb (12A380) anti-TNFSF 11 MAb (12A380) anti-CD254 MAb (12A380)
PRODUCT LINE	Chemokines & Cytokines
PRODUCT CATEGORY	RANK & RANKL

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-804-244-C100		100 µg	293.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human Mouse
CLONE:	12A380
ISOTYPE:	Mouse IgG1
CONCENTRATION:	0.5mg/ml
PURITY DETAIL:	Protein G-affinity purified.
FORMULATION:	Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:	Recombinant mouse RANKL (aa 1-317).
SPECIFICITY:	Recognizes human and mouse RANKL. Detects a band of ~40kDa by Western blot.
APPLICATION:	Flow Cytometry (see [2]) Immunohistochemistry (frozen sections (see [2])) Western Blot (4-6µg/ml)
SHIPPING:	SHIPPED ON BLUE ICE
SHORT TERM STORAGE:	+4°C
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stable for at least 6 months when stored at +4°C.

Product Specific Literature References

[1] Functional expression of receptor activator of nuclear factor kappaB in Hodgkin disease cell lines: P. Fiumara, et al.; Blood 98, 2784 (2001) Abstract; Full Text
[2] Estrogen deficiency accelerates murine autoimmune arthritis associated with receptor activator of nuclear factor-kappa B ligand-mediated osteoclastogenesis: T. Yoneda, et al.; Endocrinology 145, 2384 (2004) Abstract; Full Text
[3] Expression of bone-regulatory proteins in human valve allografts: R. Shetty, et al.; Heart 92, 1303 (2006) Abstract; Full Text

General Information

RANKL (TRANCE, OPGL, ODF) is a member of the TNF family. RANKL (receptor activator of NF-κB [RANK] ligand) or TRANCE (TNF-related activation-induced cytokine receptor) has been implicated in interactions between T cells and dendritic cells [1,2]. RANKL binds to RANK on dendritic cells, upregulates the expression of anti-apoptotic protein BcL-X_L suggesting a role in dendritic cell survival [2]. RANKL is also important in T- and B-cell maturation [3]. As OPGL (osteoprotegerin ligand) or ODF (osteoclast differentiation factor), the same protein can both activate mature osteoclasts and mediate osteoclastogenesis [4,5]. RANKL deficient mice show severe osteoporesis and complete abscence of osteoclasts as a result of lack of osteogenesis [3].

General Literature References

A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function: D.M. Anderson, et al.; Nature 390, 175 (1997) Abstract
[2] TRANCE (tumor necrosis factor [TNF]-related activation-induced cytokine), a new TNF family member predominantly expressed in T cells, is a dendritic cell-specific survival factor: B.R. Wong, et al.; J. Exp. Med. 186, 2075 (1997) Abstract; Full Text
[3] OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis: Y.Y. Kong, et al.; Nature 397, 315 (1999) Abstract
[4] Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation: D.L. Lacey, et al.; Cell 93, 165 (1998) Abstract
[5] Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand: H. Hsu, et al.; PNAS 96, 3540 (1999) Abstract; Full Text

Further Categories Containing This Product:

Monoclonal Antibodies • CD Antibodies

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