© 2008 Alexis Corporation
ALX-804-573 Revised 23-Apr-08
Monoclonal Antibody to c-erbB-2 (human) (MGR2)
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SYNONYMS anti-ErbB2 (human) MAb (MGR2)
anti-HER-2 (human) MAb (MGR2)
anti-neu (human) MAb (MGR2)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY erbB-2 / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-573-C100   100 µg 320.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: MGR2
ISOTYPE: Mouse IgG1
CONCENTRATION: 1mg/ml
FORMULATION: Liquid. In 150mM sodium chloride, pH 7.4, containing 0.02% sodium azide.
IMMUNOGEN: CaLu 3 lung carcinoma cell line.
SPECIFICITY: Recognizes an epitope present in the extracellular domain of human c-erbB-2 (HER-2; neu).
APPLICATION: Flow Cytometry
Immunohistochemistry (frozen sections)
Immunoprecipitation: Detects a band of ~185kDa.
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
HANDLING: Do not freeze.
Product Specific Literature References
Selection of monoclonal antibodies which induce internalization and phosphorylation of p185HER2 and growth inhibition of cells with HER2/NEU gene amplification: E. Tagliabue, et al.; Int. J. Cancer 47, 933 (1991) Abstract
p185 HER2/neu epitope mapping with murine monoclonal antibodies: F. Centis, et al.; Hybridoma 11, 267 (1992) Abstract
Antigenic and immunogenic mimicry of the HER2/neu oncoprotein by phage-displayed peptides: R. Orlandi, et al.; Eur. J. Immunol. 24, 2868 (1994) Abstract
General Information
The epidermal growth factor type II receptor, c-erbB2 (HER-2; neu), is a transmembrane tyrosine kinase receptor known to play an important role in coordinating the complex ErbB signalling network and to be involved in the development of breast cancer. When c-erbB-2 is overexpressed at high levels, ligand-independent activation of the c-erbB-2 receptor results in an increased mitogen-activated protein kinase and PI(3)K cell signalling, leading to increased cell proliferation. Overexpression of c-erbB-2 has been associated with resistance to chemotherapy and poor survival in several human tumors.
Further Categories Containing This Product:
Monoclonal Antibodies • Tumor Markers
 
 
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