ALEXIS Biochemicals: Gramicidin A (high purity)

ALX-350-233

Revised 30-Oct-07

Gramicidin A (high purity)
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Antibiotics - Other Signal Transduction Pathway Modulators

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-233-M001		1 mg	25.00 USD
ALX-350-233-M005		5 mg	70.00 USD

Product Specification

SEQUENCE:	HCO-Val-Gly-Ala-D-Leu-Ala-D-Val-Val-D-Val-Trp-D-Leu-Trp-D-Leu-Trp-D-Leu-Trp-NHCH₂CH₂OH
FORMULA:	C₉₉H₁₄₀N₂₀O₁₇
MW:	1882.3
CAS NUMBER:	11029-61-01
MERCK INDEX:	14: 4532
SOURCE/HOST:	Isolated from Bacillus brevis.
PURITY:	≥95%
APPEARANCE:	Off-white solid.
PURITY DETAIL:	Contaminants: gB and gC isomers: <1% (HPLC).
SOLUBILITY:	Soluble in DMSO, in the lower alcohols or in acetic acid.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

Naturally occurring ion channel forming pentadecapeptide. Causes K⁺/H⁺-exchange in mitochondria in a non-voltage dependent manner.

Product Specific Literature References

Purification of gramicidin A: C.J. Stankovic, et al.; Anal. Biochem. 184, 100 (1990) Abstract
The permeation properties of small organic cations in gramicidin A channels: S.A. Seoh & D. Busath; Biophys. J. 64, 1017 (1993) Abstract
Palmitoylation-induced conformational changes of specific side chains in the gramicidin transmembrane channel: R.E. Koeppe, 2nd, et al.; Biochemistry 34, 9299 (1995) Abstract
Two mechanisms of H+/OH- transport across phospholipid vesicular membrane facilitated by gramicidin A: B.S. Prabhananda & M.H. Kombrabail; Biophys. J. 71, 3091 (1996) Abstract
Effects of gramicidin-A on the adsorption of phospholipids to the air-water interface: S.C. Biswas, et al.; Biochim. Biophys. Acta 1717, 41 (2005) Abstract

Further Categories Containing This Product:

Peptides • K+ Channels Other Products

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