© 2008 Alexis Corporation
ALX-270-412
Revised 23-Mar-06
N-Oxalylglycine
SYNONYMS
NOG
PRODUCT LINE
Oxidative Stress
PRODUCT CATEGORY
Hypoxia-inducible Factor [HIF] / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-412-M010
10 mg
40.00 USD
ALX-270-412-M050
50 mg
120.00 USD
Product Specification
FORMULA:
C
4
H
5
NO
5
MW:
147.1
CAS NUMBER:
5262-39-5
PURITY:
≥98%
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in water or DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -20°C.
HAZARD:
IRRITANT.
Product Description
Cell permeable, competitive inhibitor of PHDs (prolyl hydroxylase domain-containing proteins; HIF-PHs).
Product Specific Literature References
Novel inhibitors of prolyl 4-hydroxylase. 3. Inhibition by the substrate analogue N-oxaloglycine and its derivatives
:
C.J. Cunliffe, et al.; J. Med. Chem.
35
, 2652 (1992)
Abstract
General Literature References
Inhibition of prolyl 4-hydroxylase by oxalyl amino acid derivatives in vitro, in isolated microsomes and in embryonic chicken tissues
:
E. Baader, et al.; Biochem. J.
300
, 525 (1994)
Abstract
Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation
:
P. Jaakkola, et al.; Science
292
, 468 (2001)
Abstract
C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
:
A.C. Epstein, et al.; Cell
107
, 43 (2001)
Abstract
Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha
:
J.M. Elkins, et al.; J. Biol. Chem.
278
, 1802 (2003)
Abstract
Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases
:
P. Koivunen, et al.; J. Biol. Chem.
279
, 9899 (2004)
Abstract
© 2008 ALEXIS Corporation,
Privacy Policy
,
Disclaimer
,
Feedback
another
CS2
website
