© 2008 Alexis Corporation
ALX-270-195
Revised 14-Jan-08
Bromoenol lactone
SYNONYMS
BEL
(
E
)-6-(Bromomethylene)tetrahydro-3-(1-naphthalenyl)-2
H
-pyran-2-one
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PLA2 Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-195-M005
5 mg
136.00 USD
Product Specification
FORMULA:
C
16
H
13
BrO
2
MW:
317.2
CAS NUMBER:
88070-98-8
PURITY:
98%
APPEARANCE:
White to off-white crystalline solid.
SOLUBILITY:
Soluble in 100% ethanol, methanol, acetonitrile, DMSO or dimethyl formamide.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Before use, product should be dissolved in an organic solvent miscible with water. Further dilutions in aqueous buffers should be made just prior to performing experiment. Store aqueous solutions on ice and use within 12 hours. Although the aqueous solutions may be stable for more than 12 hours, we strongly recommend using a fresh preparation each day.
HAZARD:
IRRITANT.
Product Description
Potent, irreversible inhibitor of Ca
2+
-independent phospholipase A
2
(iPLA
2
). Also inhibits the macrophage PLA
2
in a concentration-dependent manner. Effective enzyme-activated irreversible inhibitor of chymotrypsin.
Product Specific Literature References
Haloenol lactones. Potent enzyme-activated irreversible inhibitors for alpha-chymotrypsin
:
S.B. Daniels, et al.; J. Biol. Chem.
258
, 15046 (1983)
Abstract
;
Full Text
Suicide inhibition of canine myocardial cytosolic calcium-independent phospholipase A2. Mechanism-based discrimination between calcium- dependent and -independent phospholipases A2:
S.L. Hazen, et al.; J. Biol. Chem.
266
, 7227 (1991)
Abstract
;
Full Text
Inhibition of macrophage Ca(2+)-independent phospholipase A2 by bromoenol lactone and trifluoromethyl ketones:
E.J. Ackermann, et al.; J. Biol. Chem.
270
, 445 (1995)
Abstract
;
Full Text
Inhibition of calcium-independent phospholipase A2 prevents arachidonic acid incorporation and phospholipid remodeling in P388D1 macrophages:
J. Balsinde, et al.; PNAS
92
, 8527 (1995)
Abstract
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