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ALX-805-083 Revised 05-May-08
Monoclonal Antibody to CEACAM6 (human) (9A6)
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SYNONYMS anti-CD66c (human) MAb (9A6)
anti-NCA (human) MAb (9A6)
PRODUCT LINE Cytoskeleton
PRODUCT CATEGORY CEACAM [CD66] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-805-083-C100   100 µg 340.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: 9A6
ISOTYPE: Mouse IgG1
CONCENTRATION: 1mg/ml
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS, pH 7.2. Contains no preservatives.
IMMUNOGEN: Tumor cell lines expressing human CEACAM6.
SPECIFICITY: Recognizes human CEACAM6. Does not cross-react with human CEACAM1, 3, 4, 5, 7 or 8.
APPLICATION: Flow Cytometry
ELISA
Immunohistochemistry (frozen sections)
Western Blot
Optimal conditions must be determined individually for each application.
QUALITY CONTROL: Routinely tested by flow cytometry on BOSC cells transiently transfected with a NCA expression vector.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: For maximum product recovery after thawing, centrifuge the vial before opening the cap. After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
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Product Specific Literature References
Biochemical characterization and tissue distribution of the Cora antigen, a cell surface glycoprotein differentially expressed on malignant and benign gastrointestinal epithelia: H.G. Gottlinger, et al.; Cancer Res. 48, 2198 (1988) Abstract
Determination of the specificities of monoclonal antibodies recognizing members of the CEA family using a panel of transfectants: S. Daniel, et al.; Int. J. Cancer 55, 303 (1993) Abstract
A polymerase-chain-reaction assay for the specific identification of transcripts encoded by individual carcinoembryonic antigen (CEA)-gene-family members: J. Thompson, et al.; Int. J. Cancer 55, 311 (1993) Abstract
Expression of the CEA gene family members NCA-50/90 and NCA-160 (CD66) in childhood acute lymphoblastic leukemias (ALLs) and in cell lines of B-cell origin: H. Hanenberg; Leukemia 12, 2127 (1994)
CD66 family Workshop: Binding of myeloid blind panel antibodies and CD66 Subsection antibodies to HeLa transfectants expressing individual CD66 molecules: F. Grunert; Leukocyte Typing VI: White cell Differentiation Antigens (1996), Garland Publishing Inc., New York and London, pp. 1012
Opa binding to cellular CD66 receptors mediates the transcellular traversal of Neisseria gonorrhoeae across polarized T84 epithelial cell monolayers: J. Wang, et al.; Mol. Microbiol. 30, 657 (1998) Abstract; Full Text
CEA-related proteins on human urothelial cell lines of different transformation grades: A. Krop-Watorek, et al.; Cancer Lett. 139, 15 (1999) Abstract
Carcinoembryonic antigen family receptor specificity of Neisseria meningitidis Opa variants influences adherence to and invasion of proinflammatory cytokine-activated endothelial cells: P. Muenzner, et al.; Infect. Immun. 68, 3601 (2000) Abstract; Full Text
Carcinoembryonic antigen family members CEACAM6 and CEACAM7 are differentially expressed in normal tissues and oppositely deregulated in hyperplastic colorectal polyps and early adenomas: S. Scholzel, et al.; Am. J. Pathol. 156, 595 (2000) Abstract; Full Text
Pathogenic Neisseria trigger expression of their carcinoembryonic antigen-related cellular adhesion molecule 1 (CEACAM1; previously CD66a) receptor on primary endothelial cells by activating the immediate early response transcription factor, nuclear facto: P. Muenzner, et al.; J. Biol. Chem. 276, 24331 (2001) Abstract; Full Text
Homophilic adhesion of human CEACAM1 involves N-terminal domain interactions: structural analysis of the binding site: S.M. Watt, et al.; Blood 98, 1469 (2001) Abstract; Full Text
Nuclear factor-kappa B directs carcinoembryonic antigen-related cellular adhesion molecule 1 receptor expression in Neisseria gonorrhoeae-infected epithelial cells: P. Muenzner, et al.; J. Biol. Chem. 277, 7438 (2002) Abstract; Full Text
Carcinoembryonic antigen-related cell adhesion molecule 1 expression and signaling in human, mouse, and rat leukocytes: evidence for replacement of the short cytoplasmic domain isoform by glycosylphosphatidylinositol-linked proteins in human leukocytes: B.B. Singer, et al.; J. Immunol. 168, 5139 (2002) Abstract; Full Text
Carcinoembryonic antigen: W. Zimmermann; Wiley Encyclopedia of Molecular Medicine (2002), John Wiley & Sons Inc., New York, USA, pp. 459
Granulocyte CEACAM3 is a phagocytic receptor of the innate immune system that mediates recognition and elimination of human-specific pathogens: T. Schmitter, et al.; J. Exp. Med. 199, 35 (2004) Abstract; Full Text
General Information
The normal cross-reacting antigen (NCA) or CEACAM6 belongs to the carcinoembryonic antigen (CEA) gene family. CEACAM6 is a GPI-anchored membrane protein with a single N domain, which shows structural homology to the immunoglobulin variable domains, followed by two immunoglobulin constant-like domains.
MANUFACTURER Manufactured by GENOVAC GmbH.
General Literature References
Carcinoembryonic antigen gene family: molecular biology and clinical perspectives: J.A. Thompson, et al.; J. Clin. Lab. Anal. 5, 344 (1991), (Review) Abstract
The carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissues: S. Hammarstrom; Semin. Cancer Biol. 9, 67 (1999), (Review) Abstract
Further Categories Containing This Product:
Monoclonal AntibodiesCD Antibodies
 
 

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