ALEXIS Biochemicals: Galiellalactone

ALX-350-336

Revised 05-Apr-08

Galiellalactone
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Other Natural Products - DNA Regulation / Transcription

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-336-MC05		0.5 mg	320.00 USD

Product Specification

FORMULA:	C₁₁H₁₄O₃
MW:	194.2
CAS NUMBER:	133613-71-5
SOURCE/HOST:	Isolated from an unidentified fungus, MST-FP1889.
PURITY:	≥95% (HPLC)
APPEARANCE:	White to light tan solid.
SOLUBILITY:	Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

Originally isolated from Galiella rufa as a plant growth regulator. Inhibits IL-6 mediated signal transduction by blocking the binding of the activated STAT3 dimers to their DNA binding sites without inhibiting the tyrosine and serine phosphorylation site of the STAT3 transcription factor.

Product Specific Literature References

Screening of basidiomycetes and ascomycetes for plant regulating substances: R. Hautzel and H. Anke; Z. Naturforsch. 45c, 1094 (1990)
Inhibition of interleukin-6 signaling by galiellalactone: M. Weidler, et al.; FEBS Lett. 484, 1 (2000) Abstract
Synthesis of (-)-galiellalactone: M. Johansson and O. Sterner; J. Antibiot. (Tokyo) 55, 663 (2002) Abstract
Biologically active secondary metabolites from the ascomycete A111-95. 1. Production, isolation and biological activities: B. Kopcke, et al.; J. Antibiot. (Tokyo) 55, 36 (2002) Abstract
Galiellalactone and its biogenetic precursors as chemotaxonomic markers of the Sarcosomataceae (Ascomycota): B. Kopcke, et al.; Phytochemistry 60, 709 (2002) Abstract

header picture © micronaut.ch, another CS2 website

Online Product Ordering

Clipboard [0]

Your items will be kept only for the duration of your visit.