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ALX-350-290 Revised 18-Nov-08
Debromohymenialdisine
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SYNONYMS DBH
4-(2-Amino-4-oxo-2-imidazolin-5-ylidene)-4,5,6,7-tetrahydropyrrolo[2,3-c]azepin-8-one
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Protein Kinase Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-290-C100   100 µg 90.00 USD Add To Cart
Product Specification
FORMULA: C11H11N5O2
MW: 245.2
CAS NUMBER: 75593-17-8, 125118-55-0
SOURCE/HOST: Isolated from sponge Axinella carteri.
PURITY: ≥95% (HPLC)
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in 100% ethanol or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light. Keep under inert gas.
IDENTITY: Identity determined by 1H-NMR and MS.
Product Description
Inhibitor of G2 DNA damage checkpoint (IC50=8µM) and check point kinases 1 (Chk1) (IC50=3µM) and 2 (Chk2) (IC50=3.5µM) [1,3]. Unlike other checkpoint inhibitors DBH does not inhibit ataxia-telangiectasia mutated (ATM) or ATM-Rad3-related protein. Also inhibits MAP kinase kinase 1 (MEK-1) (IC50=881nM) but is not as potent as 10Z-hymenialdisine (Prod. No. ALX-350-289) (IC50=6nM) [2].
Product Specific Literature References
[1] Inhibition of the G2 DNA damage checkpoint and of protein kinases Chk1 and Chk2 by the marine sponge alkaloid debromohymenialdisine: D. Curman, et al.; J. Biol. Chem. 276, 17914 (2001) Abstract; Full Text
[2] Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of mitogen-activated protein kinase kinase-1 (MEK-1): D. Tasdemir, et al.; J. Med. Chem. 45, 529 (2002) Abstract
[3] G2 checkpoint abrogators as anticancer drugs: T. Kawabe; Mol. Cancer Ther. 3, 513 (2004) Abstract
Further Categories Containing This Product:
MAPK Pathway Inhibitors • Chk1 & Chk2 / Related Products • Natural Products for Cell Cycle Research • Alkaloids • Marine Natural Products
 
 
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