© 2008 Alexis Corporation
ALX-380-066 Revised 07-Apr-08
Kendomycin
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SYNONYMS (-)-TAN 2162
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antitumor Antibiotics
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-066-C100   100 µg 95.00 USD Add To Cart
ALX-380-066-C500   500 µg 370.00 USD Add To Cart
Product Specification
FORMULA: C29H42O6
MW: 486.6
CAS NUMBER: 59785-91-0
SOURCE/HOST: Isolated from Streptomyces violaceoruber.
PURITY: ≥98%
APPEARANCE: Yellow powder.
SOLUBILITY: Soluble in DMSO or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: TOXIC.

Product Description
Potent endothelin receptor antagonist. Anti-osteoporotic compound. Shows remarkable antibacterial and cytotoxic activity. Mediates its cytotoxic effects, at least in part, through proteasome inhibition.
Product Specific Literature References
2000 Structure and biosynthesis of kendomycin, a carboxylic ansa-compound from Streptomyces: A.Zeeck & H.B. Bode; J. Chem. Soc. Perkin Trans. 323 (2000)
Evidence for the mode of action of the highly cytotoxic Streptomyces polyketide kendomycin: Y.A. Elnakady, et al.; Chembiochem. 8, 1261 (2007) Abstract
Further Categories Containing This Product:
Bone Metabolism Other Products • Antibiotics - Other Signal Transduction Pathway Modulators • Endothelins [ETs] & Endothelin Receptors / Related Products • Antibiotics - Proteasome / Ubiquitin Modulators
 
 
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