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ALX-480-024 Revised 18-Jun-08
8-Bromoadenosine 3',5'-cyclic Monophosphothioate, Rp-Isomer . sodium salt
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SYNONYMS Rp-8-Br-cAMPS . Na
8-Br-cAMPS . Na, Rp-isomer
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY cAMP Derivatives
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-480-024-MC05   0.5 mg 95.00 USD Add To Cart
ALX-480-024-M001   1 mg 175.00 USD Add To Cart
Product Specification
FORMULA: C10H10BrN5O5PS . Na
MW: 423.2 . 23.0
CAS NUMBER: 129735-00-8
PURITY: ≥99% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: 250 mM soluble in water, aqueous solutions, DMSO or dimethyl formamide.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Solutions should be stored in the refrigerator and should be lyophilized and frozen for longer storage periods.
IDENTITY: Identity determined by 1H-NMR, MS and UV.

Product Description
Inhibitor of cAMP-dependent protein kinase (PKA), preferentially binding to type I PKA. Lipophilic analog of Rp-cAMPS (Prod. No. ALX-480-012, and Prod. No. ALX-480-085). Resistant to mammalian cyclic nucleotide-dependent phosphodiesterases. Significantly more lipophilic and membrane permeant as compared to Rp-cAMPS or 8-Br-cAMP (Prod. No. ALX-480-007).
Product Specific Literature References
Activation of intestinal CFTR Cl- channel by heat-stable enterotoxin and guanylin via cAMP-dependent protein kinase: A.C. Chao, et al.; EMBO J. 13, 1065 (1994) Abstract
Novel (Rp)-cAMPS analogs as tool for inhibition of cAMP-kinase in cell culture: B.T. Gjertsen, et al.; J. Biol. Chem. 270, 20599 (1995) Abstract; Full Text
Further Categories Containing This Product:
PKA Inhibitors
 
 
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