ALEXIS Biochemicals: NBD Peptide / NF-κB Blocker (cell permeable)

ALX-163-011

Revised 14-Jul-08

NBD Peptide / NF-κB Blocker (cell permeable)
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	NF-kB Pathway Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-163-011-1		1 Vial	240.00 USD

Product Specification

SEQUENCE:	GRKKRRQRRR-GG-TALDWSWLQTE-amide
FORMULA:	C₁₂₁H₂₀₂N₄₈O₃₂
MW:	2841.2
QUANTITY:	50µl
CONCENTRATION:	10mM
PURITY:	≥95% (HPLC)
FORMULATION:	Liquid. In sterile PBS.
SHIPPING:	SHIPPED ON BLUE ICE
SHORT TERM STORAGE:	-20°C
LONG TERM STORAGE:	-80°C
HANDLING:	After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. Protect from moisture. Keep on ice at all times.
POSITIVE CONTROL:	Prod. No. ALX-168-009/1

Product Description

For increased cell permeability the peptide was covalently linked to the 10 aa recognized by the TAT transporter.

Product Specific Literature References

Selective inhibition of NF-kappaB blocks osteoclastogenesis and prevents inflammatory bone destruction in vivo: E. Jimi, et al.; Nature Med. 10, 617 (2004) Abstract
Selective inhibition of NF-kappaB activation by a peptide that blocks the interaction of NEMO with the IkappaB kinase complex: M.J. May, et al.; Science 289, 1550 (2000) Abstract
Characterization of the Ikappa B-kinase NEMO binding domain: M.J. May, et al.; J. Biol. Chem. 277, 45992 (2002) Abstract