ALEXIS Biochemicals: LY-171,883

ALX-340-026

Revised 16-Jun-06

LY-171,883
SYNONYMS	1-[2-Hydroxy-3-propyl-4-[4-(1H-tetrazol-5-yl)butoxy]phenyl]ethanone
PRODUCT LINE	DNA Regulation / Transcription
PRODUCT CATEGORY	PPAR Antagonists

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-340-026-M010		10 mg	68.00 USD

Product Specification

FORMULA:	C₁₆H₂₂N₄O₃
MW:	318.4
CAS NUMBER:	88107-10-2
PURITY:	≥98%
APPEARANCE:	White to off-white crystalline solid.
SOLUBILITY:	Soluble in 100% ethanol, DMSO or dimethyl formamide. Also soluble in 0.5M aqueous sodium bicarbonate.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
USE/STABILITY:	Organic stock solutions are stable for at least six months when stored at –20°C.

Product Description

Competitive leukotriene D₄ (LTD₄) antagonist. Has also been shown to bind to the γ-isofom of the peroxisome proliferator activated receptor (PPARγ).

Product Specific Literature References

LY171883, 1-less than 2-hydroxy-3-propyl-4-less than 4-(1H-tetrazol-5- yl) butoxy greater than phenyl greater than ethanone, an orally active leukotriene D4 antagonist: J.H. Fleisch, et al.; J. Pharmacol. Exp. Ther. 233, 148 (1985) Abstract
Formation of sulphidopeptide-leukotrienes by cell-cell interaction causes coronary vasoconstriction in isolated, cell-perfused heart of rabbit: A. Sala, et al.; Br. J. Pharmacol. 110, 1206 (1993) Abstract
Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid- activated transcription factor: P. Tontonoz, et al.; Cell 79, 1147 (1994) Abstract
15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma: B.M. Forman, et al.; Cell 83, 803 (1995) Abstract

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