ALEXIS Biochemicals: Indomethacin

ALX-270-086

Revised 07-May-08

Indomethacin
PRODUCT LINE	Inflammation
PRODUCT CATEGORY	Non-Steroidal Anti-Inflammatory Drugs [NSAIDS]

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-086-G005		5 g	30.00 USD
ALX-270-086-G025		25 g	80.00 USD

Product Specification

FORMULA:	C₁₉H₁₆ClNO₄
MW:	357.8
CAS NUMBER:	53-86-1
MERCK INDEX:	14: 4968
PURITY:	≥98%
APPEARANCE:	Off-white solid.
SOLUBILITY:	Soluble in acetone or methanol; insoluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+20°C
HAZARD:	VERY TOXIC.

Product Description

Non-steroidal anti-inflammatory and analgesic agent. Inhibits prostaglandin synthesis. Far more potent for inhibition of cyclooxygenases (COX) than for inhibition of lipoxygenases.

Product Specific Literature References

Chemical and biological studies on indomethacin, sulindac and their analogs: T.Y. Shen, et al.; Adv. Drug Res. 12, 90 (1977) Abstract
Comparative effects of indomethacin, acetylenic acids, 15-HETE, nordihydroguaiaretic acid and BW755C on the metabolism of arachidonic acid in human leukocytes and platelets: H. Salari, et al.; Prostagl. Leukotr. Med. 13, 53 (1984) Abstract
Effects of indomethacin on fetal renal function, renal and umbilicoplacental blood flow and lung liquid production: K.M. Stevenson & E.R. Lumbers; J. Dev. Physiol. 17, 257 (1992) Abstract
NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro: N. Futaki, et al.; Prostaglandins 47, 55 (1994) Abstract

Further Categories Containing This Product:

Analgesic / Anti-nociceptive Agents / Related Products • COX Inhibitors

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