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ALX-580-003 Revised 19-Feb-08
1-Deoxynojirimycin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Other Signal Transduction Pathway Modulators
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-580-003-M001   1 mg 28.00 USD Add To Cart
ALX-580-003-M005   5 mg 98.00 USD Add To Cart
Product Specification
FORMULA: C6H13NO4
MW: 163.2
CAS NUMBER: 19130-96-2
SOURCE/HOST: Isolated from Bacillus subtilis strain.
PURITY: ≥98%
APPEARANCE: White to off-white crystalline solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Inhibitor of mammalian glucosidases I and II.
Product Specific Literature References
Effects of the glucosidase inhibitors nojirimycin and deoxynojirimycin on the biosynthesis of membrane and secretory glycoproteins: N. Peyrieras, et al.; EMBO J. 2, 823 (1983) Abstract
Characterization of Bacillus subtilis DSM704 and its production of 1-deoxynojirimycin: D.C. Stein, et al.; Appl. Environ. Microbiol. 48, 280 (1984) Abstract
Inhibition of N-linked oligosaccharide trimming does not interfere with surface expression of certain integral membrane proteins: B. Burke, et al.; EMBO J. 3, 551 (1984) Abstract
Purification by affinity chromatography of glucosidase I, an endoplasmic reticulum hydrolase involved in the processing of asparagine-linked oligosaccharides: H. Hettkamp, et al.; Eur. J. Biochem. 142, 85 (1984) Abstract
Inhibitors of oligosaccharide processing: U. Fuhrmann, et al.; Biochim. Biophys. Acta 825, 95 (1985) Abstract
Identification of a novel mechanism for the removal of glucose residues from high mannose-type oligosaccharides: K. Suh, et al.; J. Biol. Chem. 267, 21671 (1992) Abstract; Full Text
Deoxynojirimycin: synthesis and biological activity
: A. B. Hughes & A. J. Rudge; Nat. Prod. Rep. 11, 135 (1994), (Review) Abstract
The alpha-glucosidase inhibitor 1-deoxynojirimycin blocks human immunodeficiency virus envelope glycoprotein-mediated membrane fusion at the CXCR4 binding step: M.J. Papandreou, et al.; Mol. Pharmacol. 61, 186 (2002) Abstract
Glycosidase inhibitors as potential HIV entry inhibitors?: I. Robina, et al.; Curr. Drug Metab. 5, 329 (2004), (Review) Abstract
Further Categories Containing This Product:
Glycosidases / Related Products • Alkaloids
 
 
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