ALEXIS Biochemicals: 1,5-Isoquinolinediol

ALX-480-039

Revised 20-Oct-08

1,5-Isoquinolinediol
SYNONYMS	5-Hydroxy-1(2H)-isoquinolinone 1,5-Dihydroxyisoquinoline
PRODUCT LINE	DNA Regulation / Transcription
PRODUCT CATEGORY	PARP Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-480-039-M005		5 mg	20.00 USD
ALX-480-039-M025		25 mg	60.00 USD

Product Specification

FORMULA:	C₉H₇NO₂
MW:	161.2
CAS NUMBER:	5154-02-9
PURITY:	≥98%
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in 0.1N NaOH, methanol or in DMSO; insoluble in water and 0.1N HCl.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HANDLING:	Protect from light.
HAZARD:	IRRITANT.

Product Description

Potent inhibitor of inducible nitric oxide synthase (iNOS; NOS II) in mouse macropaghes. Potently blocks poly(ADP-ribose) polymerase-1 (PARP-1). Neuroprotectant.

Product Specific Literature References

Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosyl)transferase: M. Banasik, et al.; J. Biol. Chem. 267, 1569 (1992) Abstract; Full Text
Nitric oxide activation of poly(ADP-ribose) synthetase in neurotoxicity: J. Zhang, et al.; Science 263, 687 (1994) Abstract
Effects of inhibitors of the activity of poly (ADP-ribose) synthetase on the organ injury and dysfunction caused by haemorrhagic shock: M.C. McDonald, et al.; Br. J. Pharmacol. 128, 1339 (1999) Abstract
All trans retinoic acid induces apoptosis in acute promyelocytic NB4 cells when combined with isoquinolinediol, a poly(ADP-ribose) polymerase inhibitor: D.M. Berry, et al.; Leuk. Res. 24, 307 (2000) Abstract
Inhibition of NOS-2 induction in LPS-stimulated J774.2 cells by 1, 5-isoquinolinediol, an inhibitor of PARP: R. Olszanecki, et al.; J. Physiol. Pharmacol. 57, 109 (2006) Abstract
Substrate-assisted catalysis by PARP10 limits its activity to mono-ADP-ribosylation: H. Kleine, et al.; Mol. Cell 32, 57 (2008) Abstract

Further Categories Containing This Product:

NOS Inhibitors (NOS Induction & Enzyme Activity) • DNA Repair Other Products

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