ALEXIS Biochemicals: Topotecan . hydrochloride

ALX-350-133

Revised 28-May-08

Topotecan . hydrochloride
SYNONYMS	9-[(Dimethylamino)methyl]-10-hydroxy-(20S)-camptothecin . HCl
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Topoisomerase Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-133-M001		1 mg	30.00 USD
ALX-350-133-M005		5 mg	90.00 USD
ALX-350-133-M025		25 mg	315.00 USD

Product Specification

FORMULA:	C₂₃H₂₃N₃O₅ . HCl
MW:	421.5 . 36.5
CAS NUMBER:	119413-54-6
MERCK INDEX:	14: 9548
SOURCE/HOST:	Semisynthetic.
PURITY:	≥98% (HPLC)
APPEARANCE:	Light yellow to greenish powder.
SOLUBILITY:	Soluble in water (1mg/ml) or methanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HAZARD:	TOXIC.

Product Description

Potent antitumor agent. Inhibitor of DNA-topoisomerase. Analog of (S)-(+)-camptothecin (Prod. No. ALX-350-015). Used in chemotherapy of several different cancers.

Product Specific Literature References

Synthesis of water-soluble (aminoalkyl)camptothecin analogues: inhibition of topoisomerase I and antitumor activity: W.D. Kingsbury, et al.; J. Med. Chem. 34, 98 (1991) Abstract
In vitro and in vivo activity of topotecan against human B-lineage acute lymphoblastic leukemia cells: F.M. Uckun, et al.; Blood 85, 2817 (1995) Abstract
Clinical status and optimal use of topotecan: C.H. Takimoto & S.G. Arbuck; Oncology (Williston Park) 11, 1635 (1997), Review Abstract
Topoisomerase I inhibition with topotecan: pharmacologic and clinical issues: B. Arun & E.P. Frenkel; Expert Opin. Pharmacother. 2, 491 (2001), Review Abstract
Topotecan for the treatment of small-cell lung cancer: S.J. Nicum & M.E. O´Brien; Expert Rev. Anticancer Ther. 7, 795 (2007) Abstract