ALEXIS Biochemicals: Ac-IETD-AFC

ALX-260-110

Revised 05-Apr-05

Ac-IETD-AFC
SYNONYMS	Caspase-8 Substrate (Fluorogenic) Granzyme B Substrate (Fluorogenic)
PRODUCT LINE	Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY	Caspase Substrates

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-260-110-M005		5 mg	157.00 USD
ALX-260-110-M010		10 mg	295.00 USD

Product Specification

SEQUENCE:	Ac-Ile-Glu-Thr-Asp-AFC (AFC=7-Amino-4-trifluoromethylcoumarin)
FORMULA:	C₃₁H₃₈F₃N₅O₁₂
MW:	729.7
PURITY:	≥98% (HPLC)
APPEARANCE:	White to off-white powder.
SOLUBILITY:	Soluble in DMSO.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Keep cool and dry.

Product Description

Fluorogenic substrate for caspase-8/caspase-3 processing enzyme and granzyme B. Also a substrate for caspase-10.

Product Specific Literature References

Rapid cytochrome c release, activation of caspases 3, 6, 7 and 8 followed by Bap31 cleavage in HeLa cells treated with photodynamic therapy: D.J. Granville, et al.; FEBS Lett. 437, 5 (1998) Abstract

General Information

BACKGROUND/TECHNICAL INFORMATION

AFC has an excitation maximum of 400nm and an emission maximum of 505nm.

Further Categories Containing This Product:

Granzyme Substrates

header picture © micronaut.ch, another CS2 website

Online Product Ordering

Clipboard [0]

Your items will be kept only for the duration of your visit.