ALEXIS Biochemicals: ILEI (mouse) (recombinant)

ALX-522-119

Revised 18-Jun-08

ILEI (mouse) (recombinant)
SYNONYMS	Interleukin-like EMT Inducer (mouse) (recombinant) FAM3C (mouse) (recombinant)
PRODUCT LINE	Chemokines & Cytokines
PRODUCT CATEGORY	Chemokines & Cytokines Other Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-522-119-C010		10 µg	360.00 USD

Product Specification

MW:	~25kDa
SOURCE/HOST:	Produced in HEK 293 cells. Mouse ILEI (interleukin-like EMT inducer) (aa 25-227) is fused at the C-terminus to a FLAG^®-tag
CONCENTRATION:	0.1mg/ml after reconstitution.
PURITY:	≥95% (SDS-PAGE)
FORMULATION:	Lyophilized. Contains PBS.
ENDOTOXIN CONTENT:	<0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION:	Reconstitute with 100µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum.
SHIPPING:	SHIPPED ON BLUE ICE
SHORT TERM STORAGE:	+4°C
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stable for at least 6 months after receipt when stored at -20°C.
HANDLING:	Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.

General Information

In 2006, T. Waerner, et al. characterized ILEI as a key player in both epithelial to mesenchymal transition and late-stage carcinoma progression. EMT is a process that involves changes in gene expression, cytoskeleton organization, cell adhesion, and extracellular matrix composition. This process is important during tissue formation and organogenesis, but also during cancer progression, metastasis and chronic inflammation. ILEI is overexpressed and/or altered in intracellular localization in multiple human tumors, an event strongly correlated to invasion/EMT, metastasis formation, and survival in human colon and breast cancer.
BACKGROUND/TECHNICAL INFORMATION	Swiss-Prot link Q91VU0: FAM3C (mouse) FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER	Manufactured by Apotech Corporation.

General Literature References

Cloning, expression, and initial characterization of a novel cytokine-like gene family: Y. Zhu, et al.; Genomics 80, 144 (2002) Abstract
ILEI: a cytokine essential for EMT, tumor formation, and late events in metastasis in epithelial cells: T. Waerner, et al.; Cancer Cell 10, 227 (2006) Abstract

Further Categories Containing This Product:

Recombinant Proteins / Fusion Proteins • Cancer Other Products • Transforming Growth Factor beta [TGFbeta] & Receptors / Related Products

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