ALEXIS Biochemicals: Obestatin (mouse, rat)

ALX-164-005

Revised 04-Jul-08

Obestatin (mouse, rat)
PRODUCT LINE	Obesity & Adipokines
PRODUCT CATEGORY	Ghrelin / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-164-005-M001		1 mg	130.00 USD
ALX-164-005-M005		5 mg	480.00 USD

Product Specification

SEQUENCE:	H-Phe-Asn-Ala-Pro-Phe-Asp-Val-Gly-Ile-Lys-Leu-Ser-Gly-Ala-Gln-Tyr-Gln-Gln-His-Gly-Arg-Ala-Leu-NH₂
FORMULA:	C₁₁₄H₁₇₄N₃₄O₃₁
MW:	2516.8
PEPTIDE CONTENT:	≥80%
PURITY:	≥97% (HPLC)
FORMULATION:	Lyophilized.
SOLUBILITY:	Soluble in DMSO.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

Obestatin derives like ghrelin from proghrelin, but exhibits opposite physiological effects. Obestatin decreases food intake and body weight in rodents. Moreover, obestatin also counteracts ghrelin’s effect by decelerating gastric emptying and decreasing intestinal contractility. Obestatin binds to orphan G protein-coupled receptor GPR39. Amidation of the C-terminus seems to be important for obestatin’s activity.

Product Specific Literature References

Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin’s effects on food intake: J.V. Zhang, et al.; Science 310, 996 (2005) Abstract
Biomedicine. Separation of conjoined hormones yields appetite rivals: R. Nogueiras & M. Tschop; Science 310, 985 (2005), (Comment) Abstract

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