ALEXIS Biochemicals: Thiocolchicoside

ALX-350-374

Revised 10-Jul-08

Thiocolchicoside
SYNONYMS	2-Demethoxy-2-glucosidoxythiocolchicine
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products for Neurological Research

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-374-M001		1 mg	40.00 USD
ALX-350-374-M005		5 mg	120.00 USD
ALX-350-374-M025		25 mg	420.00 USD

Product Specification

FORMULA:	C₂₇H₃₃NO₁₀S
MW:	563.6
CAS NUMBER:	602-41-5
MERCK INDEX:	14: 9324
SOURCE/HOST:	Semisynthetic.
PURITY:	≥95% (HPLC)
APPEARANCE:	Yellow solid.
SOLUBILITY:	Soluble in water or 100% ethanol.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
HAZARD:	VERY TOXIC.
IDENTITY:	Identity determined by ¹H-NMR.

Product Description

Potent competitive antagonist of GABA_AR function. Muscle relaxant. Displays anti-inflammatory and analgesic properties. Shows strong epileptogenic and convulsant activity.

Product Specific Literature References

Review of the toxicology, pharmacodynamics and pharmacokineticss of thiocolchicoside, a GABA-agonist muscle relaxant with anti-inflammatory and analgesic actions: J.M. Janbroers; Acta Ther. 13, 221 (1987)
Focal and secondarily generalised convulsive status epilepticus induced by thiocolchicoside in the rat: G. Sechi, et al.; Seizure 12, 508 (2003) Abstract
The muscle relaxant thiocolchicoside is an antagonist of GABAA receptor function in the central nervous system: M. Carta, et al.; Neuropharmacology 51, 805 (2006) Abstract
Thiocolchicoside inhibits the activity of various subtypes of recombinant GABA(A) receptors expressed in Xenopus laevis oocytes: M.P. Mascia, et al.; Eur. J. Pharmacol. 558, 37 (2007) Abstract

Further Categories Containing This Product:

Alkaloids

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