© 2008 Alexis Corporation
ALX-430-094
Revised 04-Jul-07
Monastrol
SYNONYMS
4-(3-Hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-4
H
-pyrimidin-5-carboxylic acid ethyl ester
PRODUCT LINE
Cell Cycle
PRODUCT CATEGORY
Cell Cycle Blockers & Inhibitors/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-430-094-M001
1 mg
60.00 USD
ALX-430-094-M005
5 mg
180.00 USD
Product Specification
FORMULA:
C
14
H
16
N
2
O
3
S
MW:
292.4
CAS NUMBER:
329689-23-8
PURITY:
≥95%
APPEARANCE:
White to light yellow solid.
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
Product Description
Cell permeable non-tubulin-interacting mitosis inhibitor. Blocks mitosis (IC
50
=14µM) by binding to the mitotic kinesin Eg5.
Product Specific Literature References
Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen:
T.U. Mayer, et al.; Science
286
, 971 (1999)
Abstract
A combinatorial approach to recognition of chirality: preparation of highly enantioselective aryl-dihydropyrimidine selectors for chiral HPLC:
K. Lewandowski, et al.; J. Comb. Chem.
1
, 105 (1999)
Abstract
Evidence that monastrol is an allosteric inhibitor of the mitotic kinesin Eg5:
Z. Maliga, et al.; Chem. Biol.
9
, 989 (2002)
Abstract
Inhibition of a mitotic motor protein: where, how, and conformational consequences:
Y. Yan, et al.; J. Mol. Biol.
335
, 547 (2004)
Abstract
Monastrol, a selective inhibitor of the mitotic kinesin Eg5, induces a distinctive growth profile of dendrites and axons in primary cortical neuron cultures:
S.Y. Yoon, et al.; Cell Motil. Cytoskeleton
60
, 181 (2005)
Abstract
Interaction of the mitotic kinesin Eg5 inhibitor monastrol with P-glycoprotein:
T. Peters, et al.; Naunyn Schmiedebergs Arch. Pharmacol.
372
, 291 (2006)
Abstract
A pathway of structural changes produced by monastrol binding to Eg5:
Z. Maliga, et al.; J. Biol. Chem.
281
, 7977 (2006)
Abstract
Allosteric inhibition of kinesin-5 modulates its processive directional motility:
B.H. Kwok, et al.; Nat. Chem. Biol.
2
, 480 (2006)
Abstract
Further Categories Containing This Product:
Kinesin & Kinesin-like Proteins/Related Products
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