ALEXIS Biochemicals: Ac-DMQD-AMC

ALX-260-078

Revised 17-Jan-06

Ac-DMQD-AMC
SYNONYMS	Caspase-3 Substrate (Fluorogenic)
PRODUCT LINE	Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY	Caspase Substrates

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-260-078-M001		1 mg	42.00 USD
ALX-260-078-M005		5 mg	163.00 USD

Product Specification

SEQUENCE:	Ac-Asp-Met-Gln-Asp-AMC (AMC=7-Amino-4-methylcoumarin)
FORMULA:	C₃₀H₃₈N₆O₁₂S
MW:	706.7
PEPTIDE CONTENT:	75-95%.
PURITY:	≥98% (HPLC)
APPEARANCE:	White powder.
SOLUBILITY:	Soluble in DMSO. Dilute with distilled water or buffer. Also soluble in phosphate buffer, pH 7.5
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Keep cool and dry.

Product Description

Fluorogenic substrate for caspase-3.

Product Specific Literature References

Bid truncation, bid/bax targeting to the mitochondria, and caspase activation associated with neutrophil apoptosis are inhibited by granulocyte colony-stimulating factor: N.A. Maianski, et al.; J. Immunol. 172, 7024 (2004) Abstract
The effects of TNF-alpha and inhibitors of arachidonic acid metabolism on human colon HT-29 cells depend on differentiation status: M. Kovarikova, et al.; Differentiation 72, 23 (2004) Abstract
Interaction of polyunsaturated fatty acids and sodium butyrate during apoptosis in HT-29 human colon adenocarcinoma cells: J. Hofmanova; Eur. J. Nutrition 44, 40 (2005) Abstract

General Information

BACKGROUND/TECHNICAL INFORMATION

AMC has an excitation maximum of 380nm and an emission maximum of 460nm.

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