© 2008 Alexis Corporation
ALX-380-218
Revised 08-Apr-08
Reveromycin C
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antibiotics for Cell Cycle Research
Ordering Information
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ALX-380-218-MC25
0.25 mg
320.00 USD
Product Specification
FORMULA:
C
37
H
54
O
11
MW:
674.8
CAS NUMBER:
144860-69-5
SOURCE/HOST:
Isolated from
Streptomyces
sp. MST-AS5344.
PURITY:
≥95% (HPLC)
APPEARANCE:
White to tan solid.
SOLUBILITY:
Soluble in ethyl acetate, 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Unstable in acidic conditions.
Product Description
Antibiotic. Minor component of the reveromycin complex with similar biological profile as reveromycin A (Prod. No.
ALX-380-216
), which is a G1 phase cell cycle inhibitor and induces apoptosis in osteoclasts. Generally more potent than reveromycin A. Inhibitor of the mitogenic activity of epidermal growth factor (EGF).
Product Specific Literature References
Reveromycins, new inhibitors of eukaryotic cell growth. I. Producing organism, fermentation, isolation and physico-chemical properties:
H. Takahashi, et al.; J. Antibiot. (Tokyo)
45
, 1409 (1992)
Abstract
Reveromycins, new inhibitors of eukaryotic cell growth. II. Biological activities:
H. Takahashi, et al.; J. Antibiot. (Tokyo)
45
, 1414 (1992)
Abstract
Further Categories Containing This Product:
Antibiotics - Apoptosis Inducers & Inhibitors
•
EGFR Kinase Inhibitors
•
Cell Cycle Blockers & Inhibitors / Related Products
•
Antibiotics - Antifungal
•
Bone Metabolism Other Products
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