© 2008 Alexis Corporation
ALX-270-393
Revised 17-Jul-07
CVT-313
SYNONYMS
6-(4-Methoxybenzylamino)-2-[
bis
(2-hydroxyethylamino)]-9-isopropylpurine
PRODUCT LINE
Cell Cycle
PRODUCT CATEGORY
CDK & Cyclin Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-393-M001
1 mg
60.00 USD
ALX-270-393-M005
5 mg
240.00 USD
Product Specification
FORMULA:
C
20
H
28
N
6
O
3
MW:
400.5
PURITY:
≥98% (HPLC)
APPEARANCE:
White crystalline solid.
SOLUBILITY:
Soluble in DMSO, dimethyl formamide or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from moisture.
Product Description
Specific inhibitor of CDK2/cyclin A (IC
50
=500nM) and CDK2/cyclin E (IC
50
=500nM). Also inhibits CDK1/cyclin B (IC
50
=4.2µM) and CDK4/cyclin D1 (IC
50
=215µM).
Product Specific Literature References
CVT-313, a specific and potent inhibitor of CDK2 that prevents neointimal proliferation
:
E.E. Brooks, et al.; J. Biol. Chem.
272
, 29207 (1997)
Abstract
;
Full Text
Histone H1 phosphorylation by Cdk2 selectively modulates mouse mammary tumor virus transcription through chromatin remodeling
:
R.N. Bhattacharjee, et al.; Mol. Cell. Biol.
21
, 5417 (2001)
Abstract
;
Full Text
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