ALEXIS Biochemicals: 3-Methyl-5-AIQ . hydrochloride

ALX-270-450

Revised 08-Jan-07

3-Methyl-5-AIQ . hydrochloride
SYNONYMS	3-Methyl-5-aminoisoquinolinone . HCl
PRODUCT LINE	DNA Regulation / Transcription
PRODUCT CATEGORY	PARP Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-450-M001		1 mg	50.00 USD
ALX-270-450-M005		5 mg	200.00 USD

Product Specification

FORMULA:	C₁₀H₁₀N₂O . HCl
MW:	174.2 . 36.4
PURITY:	≥98% (NMR)
APPEARANCE:	Light brown solid.
SOLUBILITY:	Soluble in water or DMSO; poorly soluble in 100% ethanol or methanol; insoluble in dichloromethane or ethyl acetate.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HANDLING:	Protect from moisture.
IDENTITY:	Identity determined by IR, ¹H-NMR, ¹³C-NMR.

Product Description

Water-soluble, potent inhibitor of poly(ADP-ribose) polymerase-1 (PARP-1) (IC₅₀=0.23µM) in vitro. Exhibits outstanding therapeutic benefits in models of myocardial infarction, ischaemia-reperfusion of the liver and kidney, heart transplantation and acute lung inflammation.

Product Specific Literature References

Synthesis and PARP-1 inhibitory activity of 3-substituted analogues of the potent water-soluble PARP inihbitor 5-aminoisoquinolin-1-one (5-AIQ): E. C. Y. Woon, et al.; Bioorg. Med. Chem. (submitted), (2006)

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