ALEXIS Biochemicals: EM574

ALX-380-264

Revised 13-May-08

EM574
SYNONYMS	Motilide Idremcinal 8,9-Didehydro-N-demethyl-9-deoxo-6-deoxy-6,9-epoxy-N-(1-methylethyl)-erythromycin
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Antibiotics - Other Signal Transduction Pathway Modulators

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-380-264-M001		1 mg	280.00 USD

Product Specification

FORMULA:	C₃₉H₆₉NO₁₂
MW:	744.0
CAS NUMBER:	110480-13-2
SOURCE/HOST:	Semisynthetic from erythromycin A.
PURITY:	≥95% (HPLC)
APPEARANCE:	White to off-white powder.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

Agonist of the motilin receptor. Shows antimicrobial and gastrointestinal motor stimulating activity in vivo.

Product Specific Literature References

EM574, an erythromycin derivative, is a potent motilin receptor agonist in human gastric antrum: M. Satoh, et al.; J. Pharmacol. Exp. Ther. 271, 574 (1994) Abstract
Bioactive metabolites of EM574 and EM523, erythromycin derivatives having strong gastrointestinal motor stimulating activity: Y. Funabashi, et al.; J. Antibiot. 49, 794 (1996) Abstract
Vagus-dependent and vagus-independent mechanisms of action of the erythromycin derivative EM574 and motilin in dogs: N. Inatomi, et al.; Jpn. J. Pharmacol. 71, 29 (1996) Abstract
EM574, an erythromycin derivative, is a motilin receptor agonist in the rabbit: F. Sato, et al.; Eur. J. Pharmacol. 322, 63 (1997) Abstract
Effects of EM574 and cisapride on gastric contractile and emptying activity in normal and drug-induced gastroparesis in dogs: T. Tanaka, et al.; J. Pharmacol. Exp. Ther. 287, 712 (1998) Abstract
EM574, an erythromycin derivative, improves delayed gastric emptying of semi-solid meals in conscious dogs: F. Sato, et al.; Eur. J. Pharmacol. 395, 165 (2000) Abstract

General Information

MANUFACTURER

Manufactured by the Kitasato Institute, Tokyo.