© 2008 Alexis Corporation
ALX-380-264
Revised 04-Jun-08
EM574
SYNONYMS
Motilide
Idremcinal
8,9-Didehydro-N-demethyl-9-deoxo-6-deoxy-6,9-epoxy-N-(1-methylethyl)-erythromycin
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antibiotics - Other Signal Transduction Pathway Modulators
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-380-264-M001
1 mg
280.00 USD
Product Specification
FORMULA:
C
39
H
69
NO
12
MW:
744.0
CAS NUMBER:
110480-13-2
SOURCE/HOST:
Semisynthetic from erythromycin A.
PURITY:
≥95% (HPLC)
APPEARANCE:
White to off-white powder.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Images
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Product Description
Agonist of the motilin receptor. Shows antimicrobial and gastrointestinal motor stimulating activity
in vitro
and
in vivo
. Stimulates contractions of muscle strips in a concentration-dependent manner (10
-7
-10
-5
M) and this contractile effect is unaffected by pretreatment with atropine or tetrodotoxin (Prod. No.
ALX-630-002
). Binds to smooth muscle homogenates wit a Kd value of 7.8 x 10
-9
. Has orexigenic activity with affinity for the growth-hormone secretagogue receptor (GHS-R, Ghrelin Receptor).
Product Specific Literature References
Gastrointestinal motor-stimulating activity of macrolide antibiotics and the structure-activity relationship:
S. Omura, et al.; J. Antibiot.
38
, 1631 (1985)
Abstract
Macrolides with gastrointestinal motor stimulating activity:
S. Omura, et al.; J. Med. Chem.
30
, 1941 (1987)
Abstract
Motilides, macrolides with gastrointestinal motor stimulating activity. I. O-substituted and tertiary N-substituted derivatives of 8,9-anhydroerythromycin A 6,9-hemiacetal:
K. Tsuzuki, et al.; Chem. Pharm. Bull.
37
, 2687 (1989)
Abstract
EM574, an erythromycin derivative, is a potent motilin receptor agonist in human gastric antrum:
M. Satoh, et al.; J. Pharmacol. Exp. Ther.
271
, 574 (1994)
Abstract
Bioactive metabolites of EM574 and EM523, erythromycin derivatives having strong gastrointestinal motor stimulating activity:
Y. Funabashi, et al.; J. Antibiot.
49
, 794 (1996)
Abstract
Vagus-dependent and vagus-independent mechanisms of action of the erythromycin derivative EM574 and motilin in dogs:
N. Inatomi, et al.; Jpn. J. Pharmacol.
71
, 29 (1996)
Abstract
EM574, an erythromycin derivative, is a motilin receptor agonist in the rabbit:
F. Sato, et al.; Eur. J. Pharmacol.
322
, 63 (1997)
Abstract
Effects of EM574 and cisapride on gastric contractile and emptying activity in normal and drug-induced gastroparesis in dogs:
T. Tanaka, et al.; J. Pharmacol. Exp. Ther.
287
, 712 (1998)
Abstract
EM574, an erythromycin derivative, improves delayed gastric emptying of semi-solid meals in conscious dogs:
F. Sato, et al.; Eur. J. Pharmacol.
395
, 165 (2000)
Abstract
General Information
MANUFACTURER
Manufactured by the Kitasato Institute, Tokyo.
Related Products
ALX-380-274
Erythromycin
Further Categories Containing This Product:
G-Protein Coupled Receptors & Ligands Other Products
•
Neuropeptides & Receptors Other Products
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