ALEXIS Biochemicals: WS-12

ALX-420-041

Revised 21-Feb-08

WS-12
SYNONYMS	(2S,5R)-2-Isopropyl-N-(4-methoxyphenyl)-5-methylcyclohexanecarboximide
PRODUCT LINE	Neurobiology
PRODUCT CATEGORY	Neuroactive Agents Other Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-420-041-M001		1 mg	25.00 USD
ALX-420-041-M005		5 mg	75.00 USD
ALX-420-041-M025		25 mg	280.00 USD

Product Specification

FORMULA:	C₁₈H₂₇NO₂
MW:	289.4
PURITY:	≥98% (HPLC)
APPEARANCE:	White to off-white powder.
SOLUBILITY:	Soluble in 100% ethanol, methanol, ethyl acetate, methylene chloride, dimethyl formamide or acetonitrile; insoluble in water or DMSO.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
IDENTITY:	Determined by ¹H-NMR and MS.

Product Description

Cooling agent. High-affinity TRPM8 (cold menthol receptor 1; CMR1) agonist. Has an EC₅₀ value ~2’000 times lower than that of (-)-menthol (Prod. No. ALX-420-042).

Product Specific Literature References

Prospects for prostate cancer imaging and therapy using high-affinity TRPM8 activators: B. Beck, et al.; Cell Calcium 41, 285 (2007) Abstract
Characterisation of TRPM8 as a pharmacophore receptor: M. Bodding, et al.; Cell Calcium 42, 618 (2007) Abstract

ALX-420-037	Icilin
ALX-420-042	(-)-Menthol