© 2008 Alexis Corporation
ALX-380-263
Revised 09-Apr-08
Amidepsine D
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Other Natural Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-380-263-M001
1 mg
230.00 USD
ALX-380-263-MM25
2.5 mg
470.00 USD
Product Specification
FORMULA:
C
26
H
24
O
10
MW:
496.5
SOURCE/HOST:
Isolated from fungal strain FO-2943.
PURITY:
≥95% (HPLC)
APPEARANCE:
White to light pink powder.
SOLUBILITY:
Soluble in methanol (1mg/ml); insoluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Inhibitor of diacylglycerol acyltransferase (DGAT). Shows inhibitory effect in rat liver microsomes (IC
50
=17.5µM) and Raji cells (IC
50
=2.8µM). Excessive accumulation of triacetylglycerol produced by DGAT may cause fatty liver, obesity and hypertriglyceridemia, which may lead to atherosclerosis, diabetes and metabolic disorders.
Product Specific Literature References
Amidepsines, inhibitors of diacylglycerol acyltransferase produced by Humicola sp. FO-2942. I. Production, isolation and biological properties:
H. Tomoda, et al.; J. Antibiot.
48
, 937 (1995)
Abstract
Amidepsines, inhibitors of diacylglycerol acyltransferase produced by Humicola sp. FO-2942. II. Structure elucidation of amidepsines A, B and C:
H. Tomoda, et al.; J. Antibiot.
48
, 942 (1995)
Abstract
General Information
MANUFACTURER
Fungal strain courtesy of the Kitasato Institute, Tokyo.
Related Products
ALX-380-262
Amidepsine A
Further Categories Containing This Product:
Lipid Metabolism Other Products
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