ALEXIS Biochemicals: AS-252424

ALX-270-465

Revised 22-May-07

AS-252424
SYNONYMS	5-[5-(4-Fluoro-2-hydroxyphenyl)-furan-2-ylmethylene)]-thiazolidine-2,4-dione
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Phosphoinositide 3-kinase [PI(3)K] / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-465-M001		1 mg	30.00 USD
ALX-270-465-M005		5 mg	120.00 USD
ALX-270-465-M025		25 mg	480.00 USD

Product Specification

FORMULA:	C₁₄H₈FNO₄S
MW:	305.3
CAS NUMBER:	900515-16-4
PURITY:	≥98% (¹H-NMR)
APPEARANCE:	Yellow to brown crystalline solid.
SOLUBILITY:	Soluble in 100% ethanol (10mg/ml), DMSO (20mg/ml) or dimethyl formamide; also soluble in a 1:1 solution of DMSO:PBS, pH 7.4, (0.5mg/ml).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stable for at least 2 years after receip when stored at -20°C.

Product Description

Potent and selective phosphoinositide 3-kinase (PI(3)K) p110γ inhibitor shown to be selective for class IB PI(3)K-mediated cellular effects.

Product Specific Literature References

Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils: A.M. Condliffe, et al.; Blood 106, 1432 (2005) Abstract; Full Text
Furan-2-ylmethylene thiazolidinediones as novel, potent, and selective inhibitors of phosphoinositide 3-kinase gamma: V. Pomel, et al.; J. Med. Chem. 49, 3857 (2006) Abstract; Full Text

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