ALEXIS Biochemicals: AS-605240

ALX-270-462

Revised 09-Oct-07

AS-605240
SYNONYMS	5-Quinoxalin-6-ylmethylene-thiazolidine-2,4-dione
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Phosphoinositide 3-kinase [PI(3)K]/Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-462-M001		1 mg	25.00 USD
ALX-270-462-M005		5 mg	80.00 USD
ALX-270-462-M025		25 mg	320.00 USD

Product Specification

FORMULA:	C₁₂H₇N₃O₂S
MW:	257.3
PURITY:	≥95% (¹H-NMR)
APPEARANCE:	Pink to reddish brown solid.
SOLUBILITY:	Soluble in DMSO.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light. Packaged under inert gas.

Product Description

Potent, cell permeable and ATP-competitive inhibitor of phosphoinositide 3-kinase γ (PI(3)Kγ). Exhibits selectivity over other PI(3)K isoforms.

Product Specific Literature References

Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis: M. Camps, et al.; Nat. Med. 11, 936 (2005) Abstract
PI3Kgamma inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus: D.F. Barber, et al.; Nat. Med. 11, 933 (2005) Abstract

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