ALEXIS Biochemicals: PI-103

ALX-270-460

Revised 04-Sep-07

PI-103
SYNONYMS	3-(4-(4-Morpholinyl)pyrido[3’,2’:4,5]furo[3,2-d]pyrimidin-2-yl)phenol
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Phosphoinositide 3-kinase [PI(3)K]/Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-460-M001		1 mg	70.00 USD
ALX-270-460-M005		5 mg	280.00 USD
ALX-270-460-M025		25 mg	980.00 USD

Product Specification

FORMULA:	C₁₉H₁₆N₄O₃
MW:	348.4
CAS NUMBER:	371935-74-9
PURITY:	≥97% (HPLC)
APPEARANCE:	Off-white solid.
SOLUBILITY:	Soluble in DMSO (5mg/ml; warm).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stock solutions are stable for up to 3 months when stored at -20°C.
HANDLING:	Protect from light. After reconstitution, prepare aliquots and store at -20°C.

Product Description

Potent, cell permeable and ATP-competitive inhibitor of DNA-PK, phosphoinositide 3-kinase (PI(3)K), the rapamycin-sensitive (mTORC1) and rapamycin-insensitive (mTORC2) complexes of the protein kinase mTOR. Exhibits little activity towards a panel of more than 40 other kinases even at concentrations as high as 10µM. Effectively blocks cell proliferation in glioma cell lines both in vitro and in vivo.

Product Specific Literature References

A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma: Q.W. Fan, et al.; Cancer Cell 9, 341 (2006) Abstract
A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling: Z.A. Knight, et al.; Cell 125, 733 (2006) Abstract

Further Categories Containing This Product:

Mammalian Target of Rapamycin [mTOR]/Related Products

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